Ion Channels of Excitable Membranes (3rd Edition)

Book Description

Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.

Customer Reviews:

Excellent and useful text........2006-11-17

This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf.

Destined to become an Oprah Book Club selection.......2005-12-08

Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."

Even after my fifth reading, that line still gives me the shivers.

But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.

It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!

Keeps getting better with each Edition.......2002-03-27

This book is a must-have for anyone working with excitable cells, be they experimentalists or modelers. It's a great reference book; everything is clearly indexed and almost compulsively cited. I've been using this book since its first edition, and it just keeps getting better each time.

Rara avis.......2002-02-09

This classic deserves all the praise it gets. It is an excellent introduction to the molecular biology of channels, told with an eye to history as well as science.

A classic. Still authoritative........2001-08-13

This is an authoritative textbook on ion channels that is often quoted in numerous textbooks in neurophysiology. Hille himself has contributed a lot in this field. The Hogkin-Huxley model is the de facto standard model in neurophysiology but certain things about neurons cannot be explained only with voltage-controlled sodium and potassium channels. With the patch-clamp technique, we have found a way to explore other interesting channles. To remind you, there are a world of ion channels! Hille's textbook show there are indeed a variety of channels most of which are poorly understood. As a reviewer below has commented, it also gives a unique insight into the history of neural membrane research. Concepts are explained with clearity. Details measurement techniques.

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Cellular Neurophysiology and Electrophysiology
A very good book
Poorly written and hard to follow.
Aidley - Interesting and user friendly (mostly)

Physiology Of Excitable Cells
David J. Aidley
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0521574218

Book Description

The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the field. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently, there is much new material throughout the book, including many new illustrations and extensive references to recent work. The text's essential philosophy remains the same, however: it clearly explains fundamental concepts, and examines key experiments in detail. This thorough and clearly written textbook will be valuable for students of physiology, neuroscience, cell biology and biophysics.

Customer Reviews:

Cellular Neurophysiology and Electrophysiology.......2005-04-17

David Aidley's 4th edition text is superb for the graduate student in experimental cellular neurophysiology. This text does not cover neuroanatomy or systems neurophysiology. That is probably a weakness for those students hoping to have a comprehensive review book such as Principles of Neural Science by Kandel & Schwartz. Strengths of the book include discussion of Hodgkin-Huxley equations, ion channel kinetics equations, entropy equations, pearls of wisdom related to different aquatic species, etc. LTP and LTD are covered well. Receptor physiology is discussed better in this book than any other with the exception of Handbook of Physiology Receptors Springer by Lowenstein. Cortical neurophysiology is weak here. If you had to choose between this book and other cellular neurophysiology books, you cannot go wrong with this one. Cellular Biophysics: Electrical Phenomenon by Weiss and Foundations of Cellular Neurophysiology by Wu & Johnston are two others to look at that are more complex than Aidley's book. It is a shame that David Aidley died in 2001 so that a 5th edition of this outstanding textbook will not be available.

A very good book.......2002-02-23

So, You're in grad school or a major in Neurobiology and you are looking to see if the book is worth the money??

This book does not give core facts in a easy to regurgitate format.Don't read this a day before your exam.

What the book gives you and does better than any other neurobiology book I know about (yes,that's a tall claim, but Im comfortable making it) is a clear and concise walk through the relevant ideas and experiments that went into building a simple 'taken for granted' concept like say the synaptic vesicles.

This book more than any other made me see the facts I read in tons of other books through the eye of an experimentalist and I had a clear appreciation of the thought that went towards designing an experiment and interpreting the result.I'm not sure if this would be the best book to read for an introduction to Neurobiology but if you have some background this is a book you would like to come back to again and again.

Poorly written and hard to follow........2000-10-31

I am a first year graduate student in Neurobiology, and our class was assigned Aidley as our text for Neurophysiology. In short: this class has now become much more difficult because of Aidley's hard to follow style. He gives numerous details of experiments, but wholly fails to connect them to each other or to the reader. In addition, the numerous charts and graphs lend little support to the text since most often they are poorly explained and have little to do with the section in which they are placed. Each chapter follows a logical sequence, but the text within does not, jumping from descriptions of genetics experimental methods straight to physical chemistry. If you want to learn about Neurophysiology, there are many other texts to choose from, most of which the reader would find more interesting and more well written.

Aidley - Interesting and user friendly (mostly).......2000-09-06

As part of my degree I study neuromuscular physiology and this is the recomended text.It has well layed out chapters with each unit taking a major topic in electrophysiology. It starts with the extreme basic but this gives you the instant reminder of all that you've learned and the basis of electrophysiology. The chapters are layed out in the topics generally study at university, though it goes into more detail. The graphs that accompany many of the topics were found very useful for comparison for practical experiments. This text is helpful and detailed, and useful for study.

Intracellular Perfusion Cells (Ibro Handbook Series, V. 5)

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Intracellular Perfusion Cells (Ibro Handbook Series, V. 5)
Kostyuk
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Paperback

Methods in the Neurosciences, Vol. 5, Intracellular Perfusion of Excitable Cells

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Methods in the Neurosciences, Vol. 5, Intracellular Perfusion of Excitable Cells

Manufacturer: John Wiley & Sons Ltd (Import)
ProductGroup: Book
Binding: Paperback

Natural History | Nature & Ecology | Science | Subjects | Books
ASIN: 0471903795

Book Description

IBRO Handbook Series: Methods in the Neurosciences, Volume 5 General Editor: A. D. Smith Intracellular Perfusion of Excitable Cells Edited By P.G. Kostyuk and O.A.Krishtal With this Handbook Series, IBRO aims to fill a major gap in the world literature. The neuroscientist needs to be able to turn to which ever specialized method is most suited to the problem he is currently studying. Methods in the Neurosciences will help to provide expert advice on exactly how to carry out the experiments, on what difficulties can occur and on the limitations of the method. Intracellular Perfusion of Excitable Cells is the fifth book in the series. It describes in detail methods of replacing the internal medium of excitable cells with artificial solutions. The transmembrane ionic gradients and intracellular metabolic systems can then be precisely controlled in experiments investigating the electrical properties of the cellular membrane. The principles of the techniques were discovered over twenty years ago, and the first chapters discuss classic work on giant nerve and muscle fibres. However, the book compares and contrasts work on many different types of excitory cell, including isolated nerve cells and oocytes. New data are presented concerning the excitability of the somatic neural membrane. The final chapters analyse some common methodological problems, such as the isolation of cells from surrounding tissue and how to obtain reliable electrical measurements from perfused cell membranes. Enough experimental detail is given for the book to be of immediate practical use to research workers in all areas of neuroscience, including membrane biophysics, cell physiology, pharmacology, oncology and toxicology. Contents Series Preface Preface

Intracellular Perfusion and Dialysis: Application to Large Nerve and Muscle Cells

Perfusion of Small Excitable Cells using Glass Pipettes

Perfusion of Isolated Neurons Fixed in Plastic Film

Perfusion of Single Cardiomyocytes

Perfusion of Oocytes

Isolation of Neurons

Electrical Measurements on Perfused CellsSubject Index

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The Physiology of Excitable Cells
D. J. Aidley
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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The physiology of excitable cells
D.J. Aidley
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback
ASIN: B000LYO4R0

The physiology of excitable cells: Proceedings of a symposium in honor of Professor Susumu Hagiwara, held in Santa Monica, California, November 6-8, 1982 (Neurology and neurobiology)

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The physiology of excitable cells: Proceedings of a symposium in honor of Professor Susumu Hagiwara, held in Santa Monica, California, November 6-8, 1982 (Neurology and neurobiology)

Manufacturer: Alan R. Liss
ProductGroup: Book
Binding: Unknown Binding

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ASIN: 0845127047

Simulation of Wave Processes in Excitable Media (Nonlinear Science)

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Simulation of Wave Processes in Excitable Media (Nonlinear Science)
Vladimir S. Zykov
Manufacturer: Palgrave Macmillan
ProductGroup: Book
Binding: Hardcover

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Structure and Function of Excitable Cells

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Structure and Function of Excitable Cells

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Textbook of Physiology: Excitable Cells and Neurophysiology (Textbook Physiology)

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Textbook of Physiology: Excitable Cells and Neurophysiology (Textbook Physiology)
Harry, M.D. Patton
Manufacturer: Harcourt
ProductGroup: Book
Binding: Hardcover

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Amazon.com

One of the finest nonfiction writers in any lineup, Halberstam likes to alternate what he's deemed his serious work--books like The Best and the Brightest, The Fifties, and The Children--with his sporting interludes, though in his hands, sports are much, much more than fun and games. Books like The Breaks of the Game and October 1964 use sports as a prism. Culture, race, society, and history are all filtered through it, and Halberstam refocuses--and interprets--what comes out the other side.

That he would now turn his considerable abilities to exploring Michael Jordan is not surprising. Halberstam loves hoops, and Jordan not only defines the game, he defines an era. His fame crosses international borders as easily as he dribbles past half-court lines. In focusing on Jordan--as athlete and force of nature--and his osmosis from a young hoop dreamer to product pitchman to the world, Halberstam is really examining intangibles like myth and legend, celebrity and fame, wealth and image, excellence and genius, race and style, the qualities of heroism and the pursuit of perfection. "That there had been even one Michael Jordan seemed in retrospect something of a genetic fluke," he writes, "and the idea that anyone would arrive in so short a span of time and do what he did both on and off the court seemed highly unlikely." But the phenomenon that is Jordan did just that.

Understanding, even admiring, what he did, how he did it, and what it means in a basketball context and a larger one is Halberstam's goal, and, despite Jordan's lack of cooperation--or maybe because of it--Halberstam's muscular prose and thinking scores powerfully. Yet, there is a wistfulness, in the end, to Playing for Keeps; the game doesn't seem as much fun and collegial as it used to for Halberstam, and Jordan, great as he may be, emerges with less of the historic grace exhibited by Jackie Robinson, Ali, and Arthur Ashe than with a quality that Halberstam deems the athlete-explorer "in terms of going beyond previously accepted limits of what was humanly possible, and somehow by dint of physical excellence and unmatched willpower, pushing those limits forward that much more." Dazzling, certainly, but not necessarily heroic. Playing for Keeps is also available on audiocassette. --Jeff Silverman

Book Description

From The Breaks of the Game to Summer of '49, David Halberstam has brought the perspective of a great historian, the inside knowledge of a dogged sportswriter, and the love of a fan to bear on some of the most mythic players and teams in the annals of American sport. With Michael Jordan and the Chicago Bulls he has given himself his greatest challenge and produced his greatest triumph. In Playing for Keeps, David Halberstam takes the first full measure of Michael Jordan's epic career, one of the great American stories of our time. A narrative of astonishing power and human drama, brimming with revealing anecdotes and penetrating insights, the book chronicles the forces in Jordan's life that have shaped him into history's greatest basketball player and the larger forces that have converged to make him the most famous living human being in the world.

Customer Reviews:

Playing for keeps; nice but less immediate and moving.......2007-08-20

Nike turned Michael Jordan into a dream. Nike funneled in 1984 all of Nike's advertising resources in one player instead of in several teams. Nike made Michal Jordan a cultural icon and featured him as a star amidst other entertainment stars. And in the beginning Jordan didn't even like Nike sneakers. He preferred Adidas. Ultimately Nike paid Jordan in roughly 1 million dollars a year for five years. In 1984 no one realized that Nike was getting one of the great bargains of the time. Nike was a shoe company in great trouble. Michael Jordan saved Nike by his appeal to the youth. In the mean time basketball benefited from satellite reception that was just opening the world of cable television. Satellite reception facilitated cheap broadcasting. Bill Rasmussen obtained channel space on a communications satellite. His ESPN opened new broadcasting opportunities for basketball. In Playing for Keeps David Halberstam tells the tale of Michael Jordan in the broader cultural context. In this book Halberstam displays his usual journalistic skills. But somehow I missed the emotional involvement of his other books. The Summer of 49 and The Breaks of the Game learned me more about the relevance of sports.

Luuk Oost

Great Book!.......2007-06-27

As someone very familiar with Michael Jordan's career I was startled by all the new bits of information crammed in this book. Its clear Halbertstam did his homework. He employed an exhaustive interview process that yields so many new anecdotes and perspectives of Michael Jordans career. I particulary enjoyed all the stories of Jordan showing flashes of greatness early on while being recruited by North Carolina. The book makes it clear that even at those early stages while no one could predict what was to come, those around Michael had never seen anything like him.

Halbertstam also reveals the background story for many of those surrounding Jordan during his run with the Bulls. Namely Phil Jackson, Scottie Pippen, Dennis Rodman, Jerry Krause, Jerry Reinsdorf, and others. He delves into their lives, paints a picture of their character, and allows you to understand what motivated all these contrasting personalities along the way.

It must be noted that the writing of David Halbertstam is just incredible. If you're a fan of Michael Jordan or just basketball this book is a must read. The subject could not be approached by a more accomplished author.

Halberstam Hoopla.......2007-01-31

I'm not a big Halberstam fan, and this book didn't change that opinion.

The subtitular "world that he [Jordan] made" is never really explored in any depth, and this is a surface-skimming bio of Jordan with the addition of some mini-bios on major figures in his life (David Falk, Dean Smith, Phil Jackson, etc.).

The research is limited and insight is scant as Halberstam leans heavily on material already published, pulling entire sections of the book (e.g., his thumbnail bio of Jackson) from the subject's own earlier book. He returns to quote the same two or three sports writers time and again (Sam Smith - Chicago Trib and Jordan biographer - OK, but Bob Ryan - Boston Globe - a dozen quotes???).

"Playing for Keeps" is a fast-reading Jordan sketch, a 400 page magazine article, during which Halberstam defers to Jordan too frequently: no real examination of the gambling, glossed over recount of James Jordan's murder, no meaningful exploration of Jordan the global commercial icon.

For my taste, this book is another disppointment from Halberstam.

More Great Jordan Info.......2007-01-11

Halberstam does it again. With a keen eye and a knack for pulling the reader in, David Halberstam is one of our great modern writers. Just when you thought you knew Jordan, "Playing for Keeps" shades new light (not all of it flattering) on our greatest modern basketball player.

Well worth it.

Michael Jordan and his competitive nature........2007-01-04

I never thought I would be interested in a sports story. Since I live in Chicago, the Bulls championship season was huge news here. In addition, Michael Jordan was such a roll model that few people did not admire his athletic ability or his decency. This books details Michael's rise to greatness from a skinny kid in North Carolina to his superstardom in Chicago. Along the way, people get to see why basketball became such a huge sensation not only here in the United States but worldwide. Other stars are also discussed, but Jordan led the rise of basketball and the Chicago Bulls to their heights. Along with these aspects, Jerry Krause and the murder of Jordan's father are also discussed.

This is a nice read for those interested in sports and for those interested in Jordan's greatness as a player. The author keeps the focus on Jordan and how it relates to basketball. A nice read.

Playing For Keeps - Michael Jordan And The World He Made

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Playing For Keeps - Michael Jordan And The World He Made
David Halberstam
Manufacturer: Random House
ProductGroup: Book
Binding: Hardcover
ASIN: B000IXNRZO

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PLAYING FOR KEEPS. MICHAEL JORDAN and the World he Made

Manufacturer: Random House New York, NY
ProductGroup: Book
Binding: Hardcover
ASIN: B000IAJUD0

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Playing for Keeps: Michael Jordan and the World He Made
David Halberstam
Manufacturer: FRANKLIN LIBRARY
ProductGroup: Book
Binding: Hardcover
ASIN: B000OJKOMG

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Playing for Keeps: Michael Jordan and the World He Made
David Halberstam
Manufacturer: Yellow Jersey Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OON2ES

Playing for Keeps: Michael Jordan and the World He Made (The Signed First Edition Society)

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Playing for Keeps: Michael Jordan and the World He Made (The Signed First Edition Society)

Manufacturer: The Franklin Library
ProductGroup: Book
Binding: Leather Bound
ASIN: B000IBSIOG

Product Description

Franklin Library A handsome dark burnt orange leather Limited First Edition signed by the author. One of only 2,000 Limited Signed copies. With gold gilt cover designs and page edges, marbled endpapers and bound-in silk bookmark.

Playing for Keeps:michael Jordan and the World He Made( Unabridged)

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Playing for Keeps:michael Jordan and the World He Made( Unabridged)

ProductGroup: Book
Binding: Audio Cassette
ASIN: B000HD0P8W

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