Excitation-contraction Coupling And Cardiac Contractile Force (Developments in Cardiovascular Medicine)

Book Description

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction.
The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).
Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Customer Reviews:

The "Bers book" - Better than ever!.......2003-01-27

Here it is! The second edition of the classic "Bers book". Still easy to read, up to date information with many new references and a whole new chapter on action potential & ion channels in the heart. It is longer that the first edition but still focused including more than 170 excellent figures. The new edition is even more valuable than the first one, not only for students, Post-Docs, but also for experienced researchers. It is a must read for everyone who works in the field of heart research (physiology, electrophysiology, molecular biology, pathophysiology etc.). This is the reason why it is generally accepted a classic and - without question - deserves all five stars. Thank you Don Bers!

Can't wait for an updated edition.......2000-09-26

Don Bers' precious book sets a standard for making accessible a complicated research area to a specialized scientific audience. The book does not aim at attracting readers from the general public. It is written both with scientific accuracy and in a very accessible language and must be considered a "first-read" for students in biomedical science who start working on projects in cardiovascular research. And also the more advanced scientist will frequently use this great source of information for reference. It is a pity that a more current edition is not (yet?) available. This is the one and only reason why the book failed to receive five stars.

Variants of Ventricular Preexcitation: Recognition and Treatment

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Variants of Ventricular Preexcitation: Recognition and Treatment
Eduardo Sternick
Manufacturer: Blackwell Publishing
ProductGroup: Book
Binding: Hardcover

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ASIN: 1405148438

Book Description

“Variants of Ventricular Preexcitation: Recognition and Treatment provides a unique opportunity for general cardiologists and electrophysiologists to find in one text the intricacies of recognizing and treating a group of disorders that has intrigued physicians for more than 100 years.” --from the Foreword by Mark E. Josephson, MD, Chief, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, USA Drs Sternick and Wellens combine their expertise in the diagnosis and treatment of cardiac arrhythmias to bring you this complete overview of decrementally conducting accessory pathways and their role in cardiac arrhythmias. This is the first book dedicated to these special types of accessory pathways, their recognition and management. By covering the uncommon varieties of ventricular preexcitation, this book supports you in improving patient care by: bull; bull;Helping you to identify decrementally conducting AV fibers- which comprise 3-5 % of all accessory AV pathways bull;Explaining exactly what information can be obtained from the 12-lead ECG bull;Showing how to identify and localize these pathways during an electrophysiologic study bull;Detailing the proper treatment and how to treat these patients By explaining the fundamental pathophysiology as well as the diverse clinical presentation of arrhythmias, Drs Sternick and Wellens demystify the subject of the different variants of decrementally conducting accessory pathways leading to ventricular pre-excitation and their role in cardiac arrhythmias.

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Optical Integrated Circuits
Hiroshi Nishihara , Masamitsu Haruna , and Toshiaka Suhara
Manufacturer: McGraw-Hill Professional
ProductGroup: Book
Binding: Hardcover

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ASIN: 0070460922

Book Description

An indispensible guide to the uses of optical ICs, this practical volume examines the theory, fabrication techniques, and applications of the latest generation of optical devices. Focusing on the hybrid type of OIC, the book discusses passive waveguide devices, functional optical waveguide devices, micro-fabrication, optical waveguide theory, and current research problems.

Functional Integrals and Collective Excitations (Cambridge Monographs on Mathematical Physics)

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Functional Integrals and Collective Excitations (Cambridge Monographs on Mathematical Physics)
Victor Nikolaevich Popov
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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Condensed Matter Field Theory

ASIN: 0521407877

Book Description

Written by a distinguished physicist and leading researcher, this volume describes the theory and selected applications of one of the most important mathematical tools used in the theoreticial investigation of collective excitations in statistical physics. The text offers an introduction to functional integral techniques in equilibrium statistical physics, and discusses the expression of partition functions and Green functions in terms of functional integrals. Sections of the book deal with the application of functional integrals in superfluid Bose systems, systems with Coulomb interaction, and superfluid Fermi systems. The book also considers the application of the concept of Bose-condensation of auxiliary fields to the theory of crystals, heavy atoms and also to the theory of model Hamiltonians.

Acoustic Control of Turbulent Jets (Foundations of Engineering Mechanics)

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Acoustic Control of Turbulent Jets (Foundations of Engineering Mechanics)
A.S. Ginevsky
Manufacturer: Springer-Verlag
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540201432

Book Description

Results of experimental research on aerodynamic and acoustic control of subsonic turbulent jets by acoustic excitation are presented. It was demonstrated that these control methods, originated by authors, not only can intensify mixing (by acoustic irradiation at low frequency), but also notably ease it (at high-frequency irradiation). This research monograph presents the updated results of the authors supplemented by other investigations conducted in USA, Germany and Great Britain. The methods for the numerical simulation of subsonic turbulent jets under acoustic excitation are described in detail, and examples are reviewed of practical applications, including reduction of turbojet engine noise and acoustic control of self-sustained oscillations in wind tunnels.

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The Biophysical Basis of Excitability
H. G. Ferreira , and M. W. Marshall
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0521301513

Book Description

A sound knowledge of biology, mathematics, physics and chemistry in needed to understand how excitable cells function and the many basic concepts involved in acquiring this knowledge are described from first principles in this book. As these principles equally apply to other biological fields such as the study of membrane transport, artificial membranes, signal capturing, analysis in biological systems and general applications of mathematics and physics to biology, they are of general interest. An important feature of the book is the appendices, in which mathematical functions are derived, and which ensure the usefulness of the volume as a reference manual.

Optical Mapping of Cardiac Excitation and Arrhythmias

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Optical Mapping of Cardiac Excitation and Arrhythmias

Manufacturer: Blackwell Publishing Limited
ProductGroup: Book
Binding: Hardcover

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ASIN: 0879934816

Book Description

The recent explosion of knowledge in the cardiovascular field has been fueled by the development of powerful and novel technologies for assessing cardiovascular function and disease. Fluorescent imaging techniques in the heart are a major example.Despite its widespread use in basic research and implications to clinical cardiac electrophysiology, there are no definitive and authoritative sources of information on cardiac optical mapping. This is the first and only book to date that comprehensively, in a single volume, covers all aspects of the technique and application of optical mapping in the heart. Written by leading international experts in the discipline, the book contains the basic principles of optical mapping, including: voltage-sensitive fluorescence, optics, imaging, and high speed computer data acquisition. In addition to providing a primer on basic principles, the book's four main sections cover applications of optical mapping to our understanding of impulse propagation in the heart, cardiac arrhythmias, and cardiac defibrillation. Commentary is provided throughout the book from leaders in the field of clinical cardiac electrophysiology regarding implications to our understanding of arrhythmia mechanisms in patients.This book is essential for scientists, cardiac clinicians, and trainees of all backgrounds who are interested in state-of-the-art imaging approaches to biology, as well as for the investigator who is thinking about establishing an optical mapping system in his/her lab.

Inelastic Light Scattering of Semiconductor Nanostructures (Springer Tracts in Modern Physics)

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Inelastic Light Scattering of Semiconductor Nanostructures (Springer Tracts in Modern Physics)
Christian Schüller
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540365257

Product Description

Semiconductor nanostructures are a field of enormous and still-growing research interest. On one hand, they are already realized in mass products, e.g., in high-electron-mobility field-effect transistors and quantum-well lasers. On the other hand, they allow, in specially tailored systems, the investigation of fundamental properties, such as many-particle interactions of electrons in reduced dimensions. This book attempts to fill the gap between general semiconductor textbooks and research articles. It provides (i) an introduction into the basic concepts of inelastic light scattering on semiconductor nanostructures and into their fabrication and basic properties, and, (ii) a description of the most striking recent advances in this field. Each chapter is as self-contained as possible. The monograph should interest researchers, experimentalists as well as theorists, and research students working in the field. It should also be interesting for graduate students with knowledge in solid-state physics and quantum mechanics who are interested in optical spectroscopies of semiconductors.

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Nerve and Muscle Excitation
Douglas Junge
Manufacturer: Sinauer Associates
ProductGroup: Book
Binding: Paperback

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ASIN: 0878934065

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Coulomb Excitation

Manufacturer: Academic Press Inc.,U.S.
ProductGroup: Book
Binding: Hardcover
ASIN: 0120492504

Book Description

Charles Barkley has never been shy about expressing his opinions. Michael Jordan once said that we all want to say the things that Barkley says, but we don’t dare. But even die-hard followers of the all-time NBA great, the star of TNT’s Inside the NBA and CNN’s TalkBack Live, will be astonished by just how candid and provocative he is in this book—and just how big his ambitions are. Though he addresses weighty issues with a light touch and prefers to stir people to think by making them laugh, there’s nothing Charles Barkley shies away from here—not race, not class, not big money, not scandal, not politics, not personalities, nothing. “Early on,” says Washington Post columnist and ESPN talk show host Michael Wilbon in his Introduction, “Barkley made his peace with mixing it up, and decided the consequences were very much worth it to him. And that makes him as radically different in these modern celebrity times as a 6-foot-4-inch power forward.”

If there’s one thing Charles Barkley knows, it’s the crying need for honest, open discussion in this country—the more uncomfortable the subject, the more necessary the dialogue. And if the discussion leader can be as wise, irreverent, (occasionally) profane and (consistently) funny as Charles Barkley, so much the better. Many people are going to be shocked and scandalized by I May Be Wrong but I Doubt It, but many more will stand up and cheer. Like Molly Ivins or Bill O’Reilly, Charles Barkley is utterly his own thinker, and everything he says comes from deep reflection. One way or another, if more blood hasn’t reached your brain by the time you’ve finished this book, maybe you’ve been embalmed.

From the Hardcover edition.

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Charles Barkley has never been shy about expressing his opinions. Michael Jordan once said that we all want to say the things that Barkley says, but we don't dare. But even die-hard followers of the all-time NBA great, the star of TNT's Inside the NBA and CNN's TalkBack Live, will be astonished by just how candid and provocative he is in this book -- and just how big his ambitions are. Though he addresses weighty issues with a light touch and prefers to stir people to think by making them laugh, there's nothing Charles Barkley shies away from here -- not race, not class, not big money, not scandal, not politics, not personalities, nothing. "Early on," says Washington Post columnist and ESPN talk show host Michael Wilbon in his introduction, "Barkley made his peace with mixing it up, and decided the consequences were very much worth it to him. And that makes him as radically different in these modern celebrity times as a 6-foot-4-inch power forward."

If there's one thing Charles Barkley knows, it's the crying need for honest, open discussion in this country -- the more uncomfortable the subject, the more necessary the dialogue. And if the discussion leader can be as wise, irreverent, (occasionally) profane and (consistently) funny as Charles Barkley, so much the better. Many people are going to be shocked and scandalized by I May Be Wrong but I Doubt It, but many more will stand up and cheer. Like Molly Ivins or Bill O'Reilly, Charles Barkley is utterly his own thinker, and everything he says comes from deep reflection. One way or another, if more blood hasn't reached your brain by the time you've finished this book, maybe you've been embalmed.

"Charles Barkley always makes me laugh, and he always makes me think. He hasn't held anything back in his book -- if anything, this is the most personal I've ever seen him. The only whopper is the title: when has Barkley ever admitted to being wrong?"
   TIGER WOODS

"Whether you think he's wrong or right, you'll never find Charles Barkley dull, evasive or afraid. He's blunt, honest and funny as hell, a man with strong convictions and a determination to express them without fear of offending the sensibilities of more timid souls. He's got guts, and there's as much to admire in this book as there is in the man. In I May Be Wrong but I Doubt It, Barkley refers to one of my campaigns as a rough experience. It might have been, but at least I never had to post up against Sir Charles. Now that would have been really hard."
   SENATOR JOHN McCAIN

"I find Charles to be great company on the golf course. Of course, he has never been shy about his opinions, and he has not changed for this book! Charles addresses issues that are important to all of us, not just people close to the game of basketball. Frank, funny and provocative, this is a book that will stir people to think."
   DEAN SMITH

Customer Reviews:

Barkley Gets It.......2006-12-17

Charles Barkley says that the goal of his book I MAY BE WRONG is to promote dialogue. If the number of times I have referenced the book since reading it is any indication, he has succeeded. Using examples from professional sports, mass media and his personal life to illustrate American structures of power and image, he makes a convincing case that racism is a structure rather than a belief. He speaks a commonsense language that invites you into his conversation, which may surprise readers who expect arrogant rhetoric. I can't wait to read WHO'S AFRAID OF A LARGE BLACK MAN? and to see how else Mr. Barkley will use his influence to change America.

A little more Charles, please, and a little less editing.......2006-10-17

You never know what to expect when you tune in to Charles Barkley or begin reading one of his books, but it's safe to assume that it's going to be interesting and most likely controversial. This book lives up to those expectations. In it, Barkley covers a wide range of topics, many dealing with race or race relations in one way or another, and mostly in a sports setting.

I found the book to be interesting and, in many instances, enlightening, but also to be lacking in Barkely's usual charm and humor. And, although I agree with almost all of what Barkley had to say, I was somewhat disappointed in what he didn't say. By that I mean that Barkely seemed to look at the world from only his own perspective. I would like to have seen what he had to say about the other side of the coin. But no one else ever addresses that side of the coin either, so that was probably too much to expect.

My biggest disappointment with the book, however, was that, although its contents most likely reflect Barkely's true beliefs, its language doesn't appear to be his. I loved to watch Barkely perform as a player and have always enjoyed listening to him express his views and opinions. In this book, I had hoped to read what he had to say in his own words rather than in the more grammatically correct language of an editor. Simply throwing in the word s_ _t every now and then just didn't seem to cut it.

I May Be Wrong but I Doubt It.......2006-05-17

After being born in a poor Atlanta neighborhood, former NBA star, Charles Barkley shows the reader how a little hope can go a long way. Barkley begins his story growing up and playing basketball in Atlanta; his basketball skills got him a scholarship to the University of Auburn. Fortunately, Charles's mother lived near Auburn and tried to go to all of his games. As you can see, the bond between him and his mother was very strong. After years in Auburn, Charles was then drafted to the Phoenix Suns; from then on he became one of the most renowned basketball players ever. He was traded to the Houston Rockets and retired, being known as one of the best in the NBA. TNT offers Charles as a job as a studio analysis. The question on everyone's lips now is "what will Barkley do next?"
Personally, this is my favorite book. Although, I May Be Wrong but I Doubt It is an adult book, this book is perfect for those who enjoy reading popular sports books and is not easily offended. Barkley hold nothing back but manages to teach the reader some life-long morals about life.

This book is so.....Charles.......2006-02-24

Charles Barkely is truly one of a kind. Most people eather love Charles, or hate Charles. I can't get enough of the man. He is an honest man, who will not hesitate to speak his mind. I admire that about him.

The book I May Be Wrong but I doubt It i thought was great. Charles covered many topics in this book. Charles grew up in a small, poor Alabama town. Growing up, he did not have the best relationship with his father who lived across the country. Charles had many problems growing up which he overcame. He went on to play 3 years of basketball at Auburn University. He then turned pro and was drafted 5th overall by the Philidelphia 76ers. There Charles got a chance to grow as a player with great veterans on the team. Charles ended up also playing for Pheonix and Houston. He also covers a lot of other different topics in the book. He talks about racism and how wrong it is. He also talks about how America discriminates against poor people. Charles makes some very good points. If you enjoy watching Charles on TV, this is a great book for you.

Don't waste your time.......2006-02-22

I could not even get through the first chapter, Charles is not as good as he thinkes he was. I would read bootlegger's boy by Berry Switzer famous coach of the oklahoma sooners if I were looking for a good book to read.

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I may be wrong, but I doubt it
Mike Royko
Manufacturer: H. Regnery Co
ProductGroup: Book
Binding: Unknown Binding

North America | Travel | Subjects | Books
ASIN: B0006BWB0A

I MAY BE WRONG, BUT I DOUBT IT, .Signed By the Author

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I MAY BE WRONG, BUT I DOUBT IT, .Signed By the Author
Mike Royko
Manufacturer: Henry Regnery Co.
ProductGroup: Book
Binding: Hardcover
ASIN: B000VBL0XO

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