The Art of Writing Reasonable Organic Reaction Mechanisms

Book Description

Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. The treatment emphasizes unifying principles, showing how common mechanisms link seemingly disparate reactions. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.

The author has drawn on his own research and the current literature to ensure that appropriate attention is given to topics across the range of modern organic chemistry. The text is unique in its inclusion of a chapter on reactions mediated or catalyzed by transition metals, an area in which mechanistic understanding is now essential. Relatively new topics such as olefin metathesis and cycloaromatization are covered without giving short shrift to more traditional areas such as carbonyl chemistry. The text assumes a basic knowledge of organic chemistry. It can be used either in a formal course or by students working on their own, and will be particularly useful for graduate students studying for qualifying examinations. It will also be useful to students and researchers in biochemistry, pharmacology, and inorganic chemistry.

"This is an excellent and well-presented work.... The author ... has succeeded well in treating the central ideas of reactivity and selectivity in an integrated whole. The clear style of writing, the well chosen examples, and the ... concise summaries of the main points provided at the end of each chapter should enable the reader to easily consolidate what has been learned.... The book is indeed a little work of art."

-- Jens Hartung, Angewandte Chemie International Edition

"I have taught a one-credit course with this book for three years, and, uniformly, the students have rated this book highly for its clarity and for the scope of the problems. ... This book does an excellent job at its stated goal: 'to teach students to come up with reasonable mechanisms for reactions they have never seen before.'"

-- Amy Howell, Synthesis

"I have just finished my first year of graduate studies in organic chemistry at Duke University. I just wanted to let you know how much your book got me through the past year of course work.... When it came to mechanisms, I found the clarity and thoroughness I needed only in your book. It was impressive how you were able to present so much information in a clear and comprehensive manner yet keep the book so manageable in size. In addition to the text, I also was able to benefit from the problems.... Great practice!! The on-line answers are much better than looking up answers by reference.... I am reading it again this summer in preparation for my preliminary exam next spring."

-- David Gooden

Customer Reviews:

basics for organic chemist.......2007-05-10

This book is excellent for reaction mechanism. This book is helpful for the undergraduate's organic chem 2 and the grad school's reaction mechanism class. I learned how to move the electron in reasonable way. So in one word, this book is awesome book that I ever read for practicing reaction mechanism.

Excellent Book on Mechanisms.......2006-11-04

I bought this book to practice mechanisms because I'll be taking a physical organic class in the spring that uses them heavily. I used this book instead of sitting in on a sophomore organic class, because by job as a TA conflicted.

Anyway, this book is extraordinary. Dr. Grossman has taught me so many things about how to write a correct mechanism and how to recognize a bad mechanism when I see one. The book is written in a very clear and friendly manner and it's really quite hard to put down when you start reading it.

The book also has practice problems and the book's website has the answers, giving even more incentive to practice mechanisms.

Money well spent........2006-03-21

This compact but content-rich book is ideal for students who have completed at least their first year of organic chemistry (some physical chemistry is helpful but not critical) and wish to improve their understanding of the subject. The writing style is generally remarkably clear and readable; the author manages to make an inherently intimidating subject surprisingly easy to approach and understand.

I would recommend it to any student of chemistry, regardless of whether it fits into your scheduled courses.

Orgo Made Easy!.......2005-09-30

This book is a condensed version of my text book. With this book, GOD and "Orgo for dummies", I aced Organic the first time through.

Surprisingly Easy to Read and Understand.......2005-09-04

Being a PhD student in organic chemistry, I have read a lot of chemistry books in my days, and never have I come across a book that's understandable without a teacher's explanation. The numerous examples and pictures makes understanding what the author is writing about a breeze. I would highly suggest this book to anyone who is looking into pursuing a degree in Chemistry. It has already helped me out a great deal and I'm barely half way through!

Conjugated Polymers: Theory, Synthesis, Properties, and Characterization (Handbook of Conducting Polymers)

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Conjugated Polymers: Theory, Synthesis, Properties, and Characterization (Handbook of Conducting Polymers)

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Self-Doped Conducting Polymers

ASIN: 1420043587

Book Description

Many significant fundamental concepts and practical applications have developed since the publication of the best-selling second edition of the Handbook of Conducting Polymers. Now divided into two books, the third edition continues to retain the excellent expertise of the editors and world-renowned contributors while providing superior coverage of recent advances in the chemistry, physics, and materials science of conjugated and conducting organic polymers. Conjugated Polymers: Theory, Synthesis, Properties, and Characterization, the first volume in the set, focuses on the theories, synthetic methods, and basic physical aspects needed to understand the behavior and performance of conjugated polymers. The book initially examines the theories behind p-conjugated materials and electron-lattice dynamics in organic systems. Subsequent chapters detail synthesis methods and electrical and physical properties of the full family of conducting polymers, including polyacetylenes, polyanilines, poly(arylene vinylenes), poly(arylene ethynylenes), and polyheterocycles. Featuring topics central to the science and technology of conducting polymers, this book offers easy access to up-to-date information and provides the basis for the second installment in the set.

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Polymer Syntheses (Organic Chemistry)
Stanley R. Sandler , and Wolf Karo
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0126185123

Book Description

This revised and updated Second Edition of Polymer Synthesis II continues in the tradition of Volume I in presenting detailed laboratory instructions for the preparation of various polymers. Each chapter is organized by functional groups, and each chapter not only presents preparative methods, but also includes a brief introductory summary, reviews of the very latest journal articles and patents, and safety hazards and precautions. Procedures have been chosen on the basis of safety considerations and ease of being carried out with standard laboratory equipment. This comprehensive treatment of each polymer group makes Polymer Synthesis II an indispensable guide for industrial and academic chemists as well as for students in the field.

Key Features
* This revised edition:
* Covers each polymer class, heavily referencing these with patent literature to illustrate commercial applications
* Provides new and updated information for each functional group, including:
* Curing agents for epoxy resins
* Polymerization of vinyl ethers and copolymers
* Polyvinyl silfides
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* Includes a new section-- Complex Formulation--involving the preparation of polyacrylic acid and its copolymers
* Contains many new preparations, including:
* Preparation of t-butyl acrylate copolymers using the Teyssie Method
* Template polymerization of vinylimidazole on polymethacrylic acid
* Polymerization of aqueous acrylic acid using AIBN
* Preparation of polyketals by transketalization
* Copolymerization of maleic anhydride with ethyl vinyl ether
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Fine Chemicals Manufacture
A. Cybulski , J.A. Moulijn , M.M. Sharma , and R.A. Sheldon
Manufacturer: Elsevier Science
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ASIN: 044482202X

Book Description

The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.

The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

Asymmetric Oxidation Reactions (The Practical Approach in Chemistry Series)

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Asymmetric Oxidation Reactions (The Practical Approach in Chemistry Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 019850201X

Book Description

Asymmetric oxidation is a potent method for the stereo-controlled synthesis of functional highly compounds. Asymmetric Oxidation Reactions: A Practical Approach contains protocols for all the major methods of asymmetric oxidation reactions: the C-H bond, epoxidation of olefins, epoxidation using peroxides, dihydroxylation, aminohydroxyaltion, aziridination, hydroxylation of enolates and enols, Baeyer-Villiger oxidations, oxidations of sulfides, selenides, and other heteroatoms, and oxidation using biocatalysts. Each section is written by experts and as well as the protocols provides the reader with the features of the individual reactions, optimal reaction conditions, experimental precautions, and sample results. This book is therefore an indispensable laboratory companion to any chemist performing asymmetric oxidations.

Green Reaction Media in Organic Synthesis

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Green Reaction Media in Organic Synthesis
Mikami Koichi
Manufacturer: Blackwell Publishing Limited
ProductGroup: Book
Binding: Hardcover

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ASIN: 140513402X

Book Description

Green, sustainable chemistry involves the designing of chemical processes with a view to reducing or even eliminating the use and production of hazardous materials. Recent endeavors have focused on limiting the use of organic solvents and replacing them with new, environmentally benign media. The chemical industry is interested in these cost-effective, alternative solvents and processes.This book provides a broad overview of the three most commonly used green reaction media. Directed at synthetic organic chemists working in academic and industrial laboratories, it will also serve as a textbook for graduate courses on green chemistry. Successful green reactions are considered, and experimental sections at the ends of the chapters provide important practical details, with illustrations of potential applications. Sufficient information is included to allow selection of the most appropriate medium. Extensively referenced, the volume offers a point of entry into the detailed literature.

Biocatalysis in Polymer Science (Acs Symposium Series)

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Biocatalysis in Polymer Science (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
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Biocatalysis in Polymer Science provides current information on biocatalysis, which is the use of enzymes or living organisms to carry out chemical reactions. All of the authors, including the editors, are experts and practitioners of polymer biocatalysis. Topics covered in this book include synthetic polymers, natural polymers, oligomers, and monomers. These topics amply demonstrate the versatility of this technology. Organic chemists, polymer chemists, biochemists, and graduate students will find this book a useful experience.

Enzymes in Polymer Synthesis (Acs Symposium Series)

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Enzymes in Polymer Synthesis (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
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Fluorinated Surfactants: Synthesis, Properties, Applications (Surfactant Science Series, Vol 50)

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Fluorinated Surfactants: Synthesis, Properties, Applications (Surfactant Science Series, Vol 50)
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Manufacturer: Marcel Dekker
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Synthesis and Properties of Silicones and Silicone-Modified Materials (Acs Symposium Series)

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Synthesis and Properties of Silicones and Silicone-Modified Materials (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
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ASIN: 0841238049

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Synthesis and Properties of Silicones and Silicone-Modified Materials includes sections on synthesis, characterization, elastomers and reinforcement, surfaces and interfaces, copolymers, and reinforcing fillers. Synthesis and Properties of Silicones and Silicone-Modified Materials reviews recent academic and technological developments behind silicones and silicone-modified materials. Synthesis and Properties of Silicones and Silicone-Modified Materials includes sections on synthesis, characterization, elastomers and reinforcement, surfaces and interfaces, copolymers, and reinforcing fillers. Synthesis and Properties of Silicones and Silicone-Modified Materials reviews recent academic and technological developments behind silicones and silicone-modified materials.

Book Description

A spiral approach to developing concepts enables professionals to easily use this quick and ready reference. Linking new and old terminology for mathematical concepts, this guide contains a step-by-step format with numerous examples and “tips,” and an extensive index of easy-to-find topics. A four-part organization covers numerous topics under the headings of: computations, equations and formulas, measurement and geometry, and statistics and probability. For nurses, dieticians, job trainers, home schooling professionals, and consumers who want to calculate the “best financial deal” when buying a home, saving and investing money, etc.

Customer Reviews:

Attention all community college students and faculty!.......2005-04-29

Amazing little book - all of the topics are thoughtfully laid out, in an extremely coherent index, with succinct and visually appealing examples that most students should have no trouble following.

This truly is a guide to everyday math for people in manufacturing and business, without getting into anything abstract like antiderivatives or the central mean theorem, and should be the required math level for every person seeking admission to any post-secondary program.

I am consulting with my colleagues to make this a required reference item so we spend more time teaching engineering principles and less time belabouring what should be second nature by the time students finish high school - for both those with a technical and non-technical slant!

outstanding, great for the business owner.......2003-02-08

I WAS TURNED ON TO THIS MATH REF. GUIDE BY A TEACHER. EVERYTHING
THAT I HAVE NEEDED I HAVE BEEN ABLE TO FIND QUICK AND EASY.
EXPLANATIONS ARE EASY TO FOLLOW.
DARYL

Reference to Mathematics.......2002-12-30

Great source to brush up on math skills. Easy to use with high school students and parents trying to help them. Locating math topics easy.

Comments from the Author.......2002-10-29

We wrote this book in response to many requests from college and high school students, parents of middle and high school students, and working adults. Everyone said that they needed a math reference book to look up things they had forgotten, to confirm what they remembered, or to explain what they had never studied before.

The initial reactions that we have received have been very positive. We hope you also find the book helpful and we welcome your input.

Cheryl and Margie

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Prentice Hall's Reference to Mathematics: A Guide for Everyday Math
Cheryl S. Cleaves
Manufacturer: Prentice Hall
ProductGroup: Book
Binding: Paperback
ASIN: B000OHYU32

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