Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations

Book Description

Major advances in instrumentation and technology have made high-performance liquid chromatography (HPLC) a pervasive tool in virtually all areas of chemical and biomedical research today. Despite HPLC's enormous growth, technical problems still bedevil most users at least occasionally.

Based on their immensely successful short courses, Dolan and Snyder's landmark new book --Troubleshooting LC Systems--now makes available to every practicing chromatographer the authors' wealth of expertise from years of hands-on troubleshooting of real-world LC problems--problems that routinely cause crises and unproductive downtime in nearly every lab.

Believing that successful troubleshooting requires an understanding of the basics, Dolan and Snyder open by setting forth all the fundamental principles of LC operation, then move on to a microscopic description of all the elements of LC devices, to lay out their optimal preventive maintenance routines, and ultimately to offer an unprecedentedly thorough treatment of each and every facet of troubleshooting.

Displaying a special tutorial mastery--honed to a fineness during their ongoing teaching and consulting activities, and a well-received feature column in LC Magazine--the book's chapters cover: automation and robotics • approaches to troubleshooting • reactions of samples • basic separation techniques • valves, tubing, syringes • band broadening and tailing • preventive maintenance • column packing and flushing • individual LC modules • troubleshooting principles • reagents and buffering • specific problems in separation • ghost and vacancy peaks • quantitation and calibration • pumps, seals, and pistons • gradient elution problems • column composition • concentration and blockages • sample cleanup • temperature and mixing effects • detectors and recorders • column packing and flushing.

In short, Dolan and Snyder's eminently practical new guide to Troubleshooting LC Systems is an essential laboratory handbook--one that empowers expert and novice chromatographer alike to solve every sort of practical laboratory problem on a day-to-day basis. No one using an LC system should be without it!

Chromatography and Separation Science (SST) (Separation Science and Technology)

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Chromatography and Separation Science (SST) (Separation Science and Technology)
Satinder Ahuja
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0120449811

Book Description

The basic objectives of this book are to: provide basic information on chromatography and separation science; show how simple extraction and partition processes provide the basis for development of chromatography and separation science; describe the role of chromatography and separation science in various fields; discuss the role of chromatography and separation science in development of new methodology; and present new evolving methods and how to select an optimum method.

· The book covers the fundamental physical and chemical phenomena involved in separations
· Provides a concise overview of the basics of transport phenomena and thermodynamics
· Shows the importance of chromatography within separation science

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Handbook of Process Chromatography
Gail K. Sofer , and Lars Hagel
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 012654266X

Book Description

This handbook is an excellent reference for graduates and researchers in biotechnology and practitioners in the pharmaceutical industry who wish to develop a commercial chromatographic purification process. The authors guide readers through each step of the development process, beginning with basic chromatography theory and practice and incorporating examples from companies with established processes and approved biotherapeutics. They also cover properties of biological molecules, and reveal pitfalls often encountered in the process. Design strategies are discussed in depth, considering common starting materials and their impact on purification design, scale-up concerns, and validation. The authors use their extensive consulting and teaching experience to present a practical approach to developing an optimal chromatographic process, scaling it up, and meeting requirements set forth by regulatory agencies. The included diskette contains modeling exercises providing valuable insights into the influence of chromatographic parameters on separation results and the impact of process design on production costs, making the Handbook an excellent hands-on teaching tool.

Key Features
* Considers the entire scope of process chromatography, including scale up, regulatory issues, equipment, evaluation studies, scheduling, and cost-effectiveness
* Provides examples from companies with established processes and approved biotherapeutics
* Includes an appendix which lists the most pertinent regulatory documents, allowing the user to gather necessary information to comply with global regulatory expectations for process chromatography
* Contains a modeling program on the included disk

Customer Reviews:

Validation Review.......2002-07-21

Perfect for someone wanting to learn about IQ/OQ/PQ for chromatography. Easy to read. Good presentation. Useful examples. Software is great addition. Very practical approach. Plenty of useful up-to-date references. Great buy!

Methods for Affinity Based Separations for Enzymes and Proteins

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Methods for Affinity Based Separations for Enzymes and Proteins

Manufacturer: Birkhäuser Basel
ProductGroup: Book
Binding: Paperback

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 3764363053

Book Description

One major concern of biotechnology is either using enzymes or producing them. Enzyme/protein production is therefore an important starting point for biotechnology. Bioseparation or Downstream Processing constitutes about 40-90% of the total production cost. Driven by economics, highly selective technologies applicable to large-scale processing have emerged during the last decade. These technologies are slowly diffusing to enzymologists who are working on a smaller scale, looking for fast and efficient purification protocols. The affinity-based techniques (including precipitation, two-phase extractions, expanded bed chromatography, perfusion chromatography and monoliths) described in this volume provide current and new cutting-edge methods. Consequently, the book is of main interest to researchers in biochemistry, biochemical engineering and biotechnology, working either in academic or industrial sectors.

Preparative and Production Scale Chromatography (Chromatographic Science)

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Preparative and Production Scale Chromatography (Chromatographic Science)

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Book Description

Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development engineers, process development managers, bioprocess technologists, analytical and clinical chemists and biochemists, pharmacists, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.

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Expanded Bed Chromatography
Bo Mattiasson
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Crystallography | Chemistry | Science | Subjects | Books

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ASIN: 0792361237

Book Description

Expanded bed adsorption chromatography is a novel processing technique for the purification of biomolecules, combining clarification, concentration and initial purification in one step. By such an integration it is possible to reduce the number of steps in the purification process, to shorten the processing time and to improve the yields.
The technology is new, and interesting developments have taken place concerning the adsorbents, the processing technology and potential applications. Both small-scale laboratory processes and larger industrial processes are being developed.
Expanded bed chromatography is one of the most exciting new developments in downstream processing in recent years. The technology will be a standard procedure when new biotechnological processes are being developed.

Laboratory Manual for Organic Chemistry: A Microscale Approach

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Laboratory Manual for Organic Chemistry: A Microscale Approach
William R Moore , and Anthony Winston
Manufacturer: McGraw-Hill Science/Engineering/Math
ProductGroup: Book
Binding: Spiral-bound

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Organic Chemistry Demystified

ASIN: 0070430527

Book Description

This laboratory manual for organic chemistry courses provides an investigative approach for doing hands-on experimental work. It has been class-tested and fine-tuned for six years. It comprises largely non-traditional experiments that are designed to be covered in one three-hour laboratory period.

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Aqueous Two-phase Partitioning
Boris Y. Zaslavsky
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0824794613

Book Description

Covers the fundamental principles of solute partitioning in aqueous two-phase systems, explains their important practical features, and furnishes methods of characterization. The information provided by the partition behaviour of a solute in an aqueous two-phase system is examined.

Affinity Chromatography (Chromatographic Science)

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Affinity Chromatography (Chromatographic Science)
Schott
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Affinity Chromatography: Methods and Protocols (Methods in Molecular Biology)

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Affinity Chromatography: Methods and Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Book Description

Thirty-eight years after its introduction, affinity chromatography remains a key tool in the armory of separation techniques available to separation and interaction scientists. Expanded and updated from the first edition, this second edition volume aims to provide the beginner with the practical knowledge needed to develop affinity separations suitable for a variety of applications relevant to the post-genomic era.

Book Description

This easy-to-follow book covers all essential aspects and new features of MATLAB Version 6. Thorough coverage of indexing, vectorizing, and linear algebra are included. Covers integration of MATLAB with C, FORTRAN, and Java. Extensive index has been revised. Ideal as an introduction or as a reference to MATLAB.

Customer Reviews:

Great book for MATLAB beginners.......2004-10-02

This is the best book I have read about MATLAB. It covers as many topics as possible for beginners. It is written in a simple and clear format. The examples given in the book are explained step by step with the commands printed out. The summaries, tables and important notes are also listed out for the learner easy to understand. In conclusion, it is a well organized book and reference.

Good for the basics.......2004-07-02

Most of my needs are fairly simple: some arithmetic, some algebra, some graphs, all as part of what I was really working on. Matlab is a helpful tool with legible syntax, and gives a good introduction to the first few dozen things I needed.

Matlab is very extensible. There are lots of specialty packages, GUI extensions, and hooks for custom programming. Fine. That's way past what I want right now. This gets me into Matlab and gets my job done.

Maybe experts want something more, but this is a good first book for anyone already familiar with programming.

Good book for control engineers........2003-11-17

Matlab is a powerful simulation tool for control engineers. This is a good book for enough practical examples and easy read. This book gives enough background for any simulations in control engineering. For implementation with microchip "PowerPC Programming Handbook" is the only other book you need. Having minimum necessary theoretical background and these books, you can make any electro mechanical systems work.

The best Matlab book available........2003-01-29

Version 6 of Matlab is improved in graphic use interface and efficiency of computation as well as compatibility with other languages like C++. "Mastering MATLAB 6" is the best choice of book on Matlab for its detailed coverage on graphics and interface with other programming languages. Only weakness of Matlab is its capability of analytical computation, and it is preferred to use Maple for analytical calculation. The most respected programming book on Maple is "Maple Programming Guide". "Mastering MATLAB 6" and "Maple Programming Guide" are the investment which you will not regret.

Wonderfully thorough reference.......2002-09-28

This book is exactly what I've been looking for. It's a fantastic reference for all that is Matlab. I'm a graduate student who does numerical methods in Matlab frequently and to have a book like this handy is a real help.

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MASTERING MATLAB 6
HANSELMAN
Manufacturer: Prentice Hall
ProductGroup: Book
Binding: Paperback
ASIN: B000OHIO4I

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