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Chiral Chromatography
Thomas E. Beesley , and
Raymond P. W. Scott
Manufacturer: Wiley
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Binding: Hardcover
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ASIN: 0471974277 |
Book Description
Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included:
* chiral separations involving both gas and liquid chromatography
* descriptions of the apparatus used for both techniques
* detailed discussion on the retention mechanism that results in chiral selectivity
* the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography
* preparative applications for large scale purification of enantiomers
* applications of capillary electrophoresis and capillary electrochromatography.
In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.
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Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis
Imran Ali , and
Hassan Y. Aboul-Enein
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover
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ASIN: 0470867809 |
Book Description
Today, among the various chiral discrimination methods, chromatography and capillary electrophoresis techniques have become powerful tools in environmental analysis. Therefore, there is a need to describe the art of the determination of the chiral pollutants in the environmental matrices. This book provides the complete information on the types of the chiral pollutants, their toxicities and methods of determination by chromatography and capillary electrophoresis.
Download Description
Adam Hart Davis has interviewed some of the most influential scientists and thinkers of our time. In this fascinating insight into modern science he presents the stories behind the science, the difficulties behind the discoveries and the future of the findings, as explained by the people themselves.
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Chiral Separation Techniques
Manufacturer: Wiley-VCH
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Binding: Hardcover
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ASIN: 3527298754 |
Book Description
This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques.
From reviews of the previous edition:
"A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field" --European Journal of Drug Metabolism
"The dense mass of information contained in this book will make it a valuable resource..." --Chemical Engineering Research "... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field" --The Analyst
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Chiral Separations (Chromatographic Society Symposium)
D. Stevenson , and
I.D. Wilson
Manufacturer: Springer
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Binding: Hardcover
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ASIN: 0306432528 |
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Chiral Separations by Chromatography (American Chemical Society Publication)
Satinder Ahuja
Manufacturer: An American Chemical Society Publication
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ASIN: 0841236313 |
Book Description
The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.
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Chiral Separations by Liquid Chromatography (Acs Symposium Series)
Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover
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ASIN: 0841221162 |
Book Description
A definitive reference for researchers working on problems involving chirality. Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques. Four chapters provide a detailed review of the commonly used columns: brush type, cyclodextrin, polysaccaride carbonate, and protein. Many of the papers focus on HPLC, a technique which is also ideally suited for large scale preparation of optical isomers. In addition, the volume provides significant discussion on the use of chiral discriminators or selectors.
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Chiral Separations by Liquid Chromatography: Theory and Applications (Chromatographic Science, Vol. 90) (Chromatographic Science)
Hassan Y. Aboul-Enein , and
Imran Ali
Manufacturer: CRC
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ASIN: 0824740149 |
Book Description
Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography, and thin layer chromatography. Readers will find: · viable optimization techniques for enantiomeric resolution on various types of CSPs · new strategies in liquid chromatography and related technologies of chiral separations · a valuable resource filled with 1200 of the most recent and relevant literature citations
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Chiral Separations: Applications and Technology (ACS Professional Reference Books)
Manufacturer: An American Chemical Society Publication
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Binding: Hardcover
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ASIN: 0841234078 |
Book Description
Chronicles the theory and practical applications of chiral technology by focusing on the efficient preparation, isolation, and separation of chiral molecules in optically pure forms. Discusses asymmetric synthesis and chiral resolution in a variety of contexts, including enantioselective reactions and additions, enzyme-catalyzed reactions, chromatographic methods with various chiral stationary phases or chiral discriminators, and enantioselective membrane transport.
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Chromatographic Chiral Separations (Chromatographic Science)
Morris Zief
Manufacturer: Marcel Dekker
ProductGroup: Book
Binding: Hardcover
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ASIN: 0824777867 |
Book Description
Citation Details
Distributed by ProQuest Information and Learning
Book Description
Coevolution—reciprocal evolutionary change in interacting species driven by natural selection—is one of the most important ecological and genetic processes organizing the earth's biodiversity: most plants and animals require coevolved interactions with other species to survive and reproduce. The Geographic Mosaic of Coevolution analyzes how the biology of species provides the raw material for long-term coevolution, evaluates how local coadaptation forms the basic module of coevolutionary change, and explores how the coevolutionary process reshapes locally coevolving interactions across the earth's constantly changing landscapes.
Picking up where his influential The Coevolutionary Process left off, John N. Thompson synthesizes the state of a rapidly developing science that integrates approaches from evolutionary ecology, population genetics, phylogeography, systematics, evolutionary biochemistry and physiology, and molecular biology. Using models, data, and hypotheses to develop a complete conceptual framework, Thompson also draws on examples from a wide range of taxa and environments, illustrating the expanding breadth and depth of research in coevolutionary biology.
Customer Reviews:
A wonderful compendium of information.......2006-09-19
A superbly written text available at a super price. Sums up much of what is known and not known about the coevolutionary process. Does a great job at explaining the theory and critical importance of symbiotic interactions to understanding general ecology and evolution. Also summarizes most of what he wrote about in his earlier books on this subject. The chapters range from the population level to large geographical scales. Three entire chapters on "antagonists" and three entire chapters on "mutualists". Good balance of theory and empirical examples. [Yes, I am an ecologist!] Highly recommended...
The Origin of Ecologies by Means of Natural Selection.......2006-01-13
We all know of examples of coevolution. The variety of flowering plants and their pollinators is a spectacular example. But this book looks at coevolution on a very small scale. For example, in parts of the Rocky Mountains where crossbill birds are the main eaters of the seeds of lodgepole pines, the cones have evolved mostly to defend against the birds and the birds' bills have evolved mostly to counter those defenses. This is coevolution. But there are also many regions in the Rockies where the primary eaters of pine seeds are squirrels or moths. In those regions those animals mostly shape the cones and the birds bills evolve accordingly. Such regional variations constitute the geographical mosaic of the title.
This book was written to convince researchers that the geographic mosaic of evolution is much more important than most evolution researchers recognize. It contains many, many examples such as the crossbills, and it states many general principles, which are often very similar to previous principles. It has none of the glamour or scope of, say, an account of the transition from fishes to land-dwelling animals. Instead, it is about how researchers study the working of evolution from generation to generation, and that is the level at which evolution actually works. I think anyone who is seriously interested in evolution should read one such book in his lifetime. This book is a good one because the examples aren't too technical. Be prepared to skim over some sections, and to decide which sections you can skim over without losing continuity.
It is also worth noting that, as in most academic writing, nothing is said in plain English if it can be expressed in jargon.
The last chapter deals with something entirely new in evolution: intelligent design. Humans are promoting some forms (through breeding and other forms of genetic engineering), demoting others (by pest control, antibiotics, et al.), and massively transforming environments (e.g. cities and farms). These present unique problems for evolution researchers because they are much faster than "natural" evolution. But they may well be the most important for the future of the species closest to our hearts.
(For more about where this review is coming from, you can click on my name, above.)
Amazon.com
Some revolutions are thoroughly televised. When Douglas Engelbart first demonstrated small-w windows and a funny wooden device called a mouse back in 1968, interest jumped quickly and he became the progenitor of the PC. Now, less widely known than the successful entrepreneurs who made billions from his innovations, his story deserves deeper attention as an outstanding example of practical creative research. Communications professor Thierry Bardini examines the scope of his work before and during his tenure at the Stanford Research Institute in Bootstrapping, a thoughtful history of an underreported story.
Bardini cleverly sidesteps the postmodern superanalysis of his colleagues to present a clear, straightforward glimpse into Engelbart's environment of inspiration. As an engineer familiar with the earliest computers, he quickly came to understand that their complexity could rapidly outpace human ability to cope--and thus was born the concept of the "user." His team used their computing power to determine how best to use their computing power--a reflexive assignment of profound brilliance--and churned out novel concepts and designs faster than their contemporaries could absorb them.
How and why this occurred as it did is the focus of Bardini's research, and students of creativity and the history of computing will have fits of ecstasy that he has compiled his work so accessibly. Better still, Bootstrapping shows research done right and is essential reading for R&D types everywhere. --Rob Lightner
Book Description
Bootstrapping analyzes the genesis of personal computing from both technological and social perspectives, through a close study of the pathbreaking work of one researcher, Douglas Engelbart. In his lab at the Stanford Research Institute in the 1960s, Engelbart, along with a small team of researchers, developed some of the cornerstones of personal computing as we know it, including the mouse, the windowed user interface, and hypertext. Today, all these technologies are well known, even taken for granted, but the assumptions and motivations behind their invention are not. Bootstrapping establishes Douglas Engelbart’s contribution through a detailed history of both the material and the symbolic constitution of his system’s human-computer interface in the context of the computer research community in the United States in the 1960s and 1970s.
Engelbart felt that the complexity of many of the world’s problems was becoming overwhelming, and the time for solving these problems was becoming shorter and shorter. What was needed, he determined, was a system that would augment human intelligence, co-transforming or co-evolving both humans and the machines they use. He sought a systematic way to think and organize this coevolution in an effort to discover a path on which a radical technological improvement could lead to a radical improvement in how to make people work effectively. What was involved in Engelbart’s project was not just the invention of a computerized system that would enable humans, acting together, to manage complexity, but the invention of a new kind of human, “the user.” What he ultimately envisioned was a “bootstrapping” process by which those who actually invented the hardware and software of this new system would simultaneously reinvent the human in a new form.
The book also offers a careful narrative of the collapse of Engelbart’s laboratory at Stanford Research Institute, and the further translation of Engelbart’s vision. It shows that Engelbart’s ultimate goal of coevolution came to be translated in terms of technological progress and human adaptation to supposedly user-friendly technologies. At a time of the massive diffusion of the World Wide Web, Bootstrapping recalls the early experiments and original ideals that led to today’s “information revolution.”
Customer Reviews:
Uneven, but interesting account of Engelbart's crusade........2005-05-24
While possibly everyone even mildly interested in the history of GUIs will have heard of Doug Engelbart's groundbreaking "mother of all demos" of oNLine System from 1968, there's usually much less emphasis on its history, relevance and context. "Bootstrapping" provides this knowledge, giving a detailed history of Doug Engelbart's "crusade" -- starting with his studies and ending with the closure of Augmentation Research Center. It also positions NLS in a broader context of Engelbart's vision of the symbiosis of the user and the system, which went much further and deeper than just the mouse and proto-hypertext (that's not to say that these inventions do not get their fair share of attention in the book). Superbly researched, the book suffers from sometimes overly dry and scholarly tone, going into unnecessary details, and perhaps exhibiting too much sympathy for Engelbart. However, it's worth its cover price, even if for accurate portrayal of the future that hasn't been.
Story of a little known pioneer!.......2001-08-05
These days only the big guys get the credit for the technology we use every day. In Bootstrapping, Bardini looks at the life and contributions of Douglas Engelbart to the personal computing revolution. More than the story of technology, Bootstrapping is the story of a personal crusade to make interfacing with computers easier. Bardini focuses too much on the person and not enough on the context of Engelbart's innovations, hence the 4 stars.
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Interaction and Coevolution
John N. Thompson
Manufacturer: John Wiley & Sons Inc
ProductGroup: Book
Binding: Hardcover
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ASIN: 0471090220 |
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