Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)

Book Description

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.

Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included.

Product Description

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as we as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.

PROTEIN CRYSTALLOGRAPHY IN DRUG DISCOVERY

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PROTEIN CRYSTALLOGRAPHY IN DRUG DISCOVERY
RE BABINE
Manufacturer: JOHN WILEY AND SONS LTD
ProductGroup: Book
Binding: Paperback
ASIN: B000N5EZTE

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Protein Crystallography in Drug Discovery
RE BABINE
Manufacturer: JOHN WILEY AND SONS LTD
ProductGroup: Book
Binding: Paperback
ASIN: B000N5DEF0

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Trilobites; 300 million years of success

An arthropod's view of Paleozoic Earth

Nice read

A delightful invitation, a disappointing primer (borrowed from another reviewer)

Brilliant! (from a Trilobite collector)

Trilobite: Eyewitness to Evolution
Richard Fortey
Manufacturer: Vintage
ProductGroup: Book
Binding: Paperback

Fossils | Animals | Biological Sciences | Science | Subjects | Books
General | Evolution | Science | Subjects | Books
General | Science | Subjects | Books
General | Evolution | Professional Science | Professional & Technical | Subjects | Books
Similar Items:

Life: A Natural History of the First Four Billion Years of Life on Earth

Earth: An Intimate History

Trilobites

Fossils: The Key to the Past

Trilobites: Common Trilobites of North America (A NatureGuide book)

ASIN: 0375706216
Release Date: 2001-11-13

Amazon.com

With his new book Trilobite! Eyewitness to Evolution, Richard Fortey confirms his status as one of the best communicators of science around today. His hugely enjoyable previous book, Life: A Natural History of the First Four Billion Years of Life on Earth, was shortlisted for the 1998 Rhone-Poulenc science book prize, but Trilobite! is sure to receive even greater acclaim. Whereas Life took the reader on a whistle-stop tour of evolution from start to present--a huge undertaking that necessarily granted little space to each time period or taxonomic group--Trilobite! sees Fortey indulging in a whole book about his overriding paleontological passion, the long extinct and enigmatic creatures of the title. The result is a joy.

Trilobites--woodlicelike creatures that dominated the world's oceans long before the time of the dinosaurs--are, arguably, the most beautiful animals that have ever been chipped out of the fossil record. Fortey certainly seems to think so. His enthusiastic, almost loving explanations of the anatomy, ecology, and long evolutionary history of these fascinating vanished creatures carry the reader on an inspirational journey into the Earth's distant past. But the book is much more than a technical treatise on trilobites. We learn about Fortey himself, his formative years as an amateur then professional paleontologist, about his much-loved teachers and colleagues, and above all, about that strange but addictive pastime known as science. You may not find arthropods as charming as Fortey does, but you will not fail to be charmed by the author. A delightful read. --Chris Lavers, Amazon.co.uk

Book Description

With Trilobite, Richard Fortey, paleontologist and author of the acclaimed Life, offers a marvelously written, smart and compelling, accessible and witty scientific narrative of the most ubiquitous of fossil creatures.

Trilobites were shelled animals that lived in the oceans over five hundred million years ago. As bewilderingly diverse then as the beetle is today, they survived in the arctic or the tropics, were spiky or smooth, were large as lobsters or small as fleas. And because they flourished for three hundred million years, they can be used to glimpse a less evolved world of ancient continents and vanished oceans. Erudite and entertaining, this book is a uniquely exuberant homage to a fabulously singular species.

Customer Reviews:

Trilobites; 300 million years of success.......2006-02-21

Richard Fortey does a good job of describing his lifetime devotion to understanding trilobites and how they fit into the evolution of life. The book is well written and with only minimal technical jargon and Latin names. It does shed light on how the trilobites can be used to trace geological changes and continental shifts over those vast time periods. From reading Fortey's book, I came away with a new interest in trilobites and their role in evolution.

An arthropod's view of Paleozoic Earth.......2005-10-01

Natural history, deep-time may conjure up images of Stephen J. Gould's wondrous creatures of the early Cambrian (530 million years ago), dug out of the Burgess Shale in British Columbia. I realize that other paleontologists have had problems with some of his anatomical descriptions and theories of punctuated equilibrium ("Trilobite" spends a chapter defending Gould from some of his more vigorous critics), but the world that he created was strange, beautiful, and compelling.

Fortey creates a similar vision of Earth as it existed for 300 million years, starting like Gould, in the Cambrian. No animal better exemplifies the drama of evolution and extinction than trilobites, except perhaps for the Johnny-come-lately dinosaurs. If you are interested in really deep time, you must travel back before the dinosaurs and peer with the author through the eyes of the trilobites. "'Look into my eyes,' the trilobite seems to say, 'and you will see the vestiges of your own history.'"

And very strange eyes they are. In the chapter, "Crystal Eyes" the author plays an exuberant, complex riff on vision as it first evolved, and most specifically on the uniquely developed eyes of trilobites. I used to think of these creatures as mud-colored tripartite beetles that crawled around in warm, shallow Paleozoic seas--interesting basically because they lasted so long. But according to Fortey, their eyes were made of calcite crystals, which "makes them unique in the animal kingdom...Look into a crystal of Iceland spar and you can see the secret of the trilobyte's vision." The author then goes into quite a bit of detail as to why double vision was not a problem for these amazing arthropods, even though their eyes were made up of six-sided crystals.

Since the trilobite's eyes were part of its exoskeleton and just as hard, it had to shed them with each molt.

Trilobites ranged from dinner-platter-size down to bitty little bugs that were barely a millimeter long. Fortey describes them in loving detail and also defends the need to collect and study them. Lord Rutherford's remark that 'all science is either physics or stamp collecting' is vigorously repudiated (I think Rutherford's aphorism must have really stung, because it gets a good bashing in nearly every natural history book in my library). Just one of the reasons why trilobites are not like stamps is that their distribution helps us determine the outlines of continents and islands that predated not just the modern world, but the ancient supercontinent of Pangaea.

Trilobites managed to squeeze through a couple of evolutionary bottlenecks, surviving and multiplying for over 300 million years. In his heart of hearts, the author admits to hoping that, like the ancient coelacanth, a remnant of this once-vast family of arthropods will be rediscovered, curled up on some unexplored sea bottom, or gazing through crystalline eyes at some newer denizen of the deep.

After reading Fortey's fascinating account, I can only hope the same.

Nice read .......2005-09-25

Truly a joy to read. This book is excellent for beginners. The author's writting style kept my intrest while the many photos and illustrations were visually stunning. Concise and imformative, I think the "average joe" will be very pleased.

A delightful invitation, a disappointing primer (borrowed from another reviewer).......2005-09-18

This was an excellent book and I greatly appreciate the enthusiasm of the author. I would have like to learn more specifics about trilobites, I would have liked more pictures, and mostly I would have liked to understand better how the author (or the scientific community) come to some of the amazing conclusions they have. For example, I didn't think it was explained well enough how they know that a small fossil is a less mature (rather than a completely different) trilobite. Also, I would have appreciated more information on how they came to their conclusions about the eye-structure (some of the pictures look pretty inconclusive to me). On the other hand, the author goes into good detail about how the community has learned about the legs and other fine details of these creatures (features that are not easily preserved nor safely hammered out of the rocks either).

I particularly enjoyed the conversational writing of the author. For me one of the best parts of this book was how he weaved scientific endeavors with history, literature, and other human activities. He talked a lot about the scientific philosophy and people in this small community, the camaraderie and competition, past and present. For sure this is a book written from a perspective, but Richard Fortey never represents it as anything else. To my mind it is a fair and refreshing perspective, so I appreciate this book. The silly reviewer from Helsinki didn't like his perspective because it did not have enough creationism in it, but at least Dr. Fortey has the integrity and intelligence to clearly state his position and process.

So why did it give trilobite three stars? It was a difficult decision, perhaps the book deserves four stars but though I learned a lot, I simply would have liked to learn more about the science. For me the one huge shortcoming of this book was the pictures and illustrations. There are two sections of "plates" printed on higher-quality paper; there are two indexes at the beginning of the book, one for "illustrations" in the text and another for the "plates" in separate sections. Additionally, there is an index in the back of the book that is completely separate from the two previous indexes, and did not seem very complete to me because every time I tried to use it to find something mentioned earlier I was not able to find it. I don't know if this is the common method in scientific publications, but I did not find it helpful. The selection of pictures seemed arbitrary to me and I don't like pictures in separate sections. All the pictures were black and white so I really don't see why they cannot be printed on the same paper. If the paper quality is too poor to keep a picture, then why are there also pictures in the text? If pictures in the text are too disruptive, then again, why are not all the pictures in separate sections? It doesn't make sense to me. There were many references to trilobites and their features (or similar ones) that had pictures but the text did not reference where. Even worse, there are many references to trilobites and their features that the author was obviously very familiar with but I could not make a clear picture in my mind because I could find no illustrations of them at all.

So in conclusion, I would recommend reading this very good book, but I would recommend buying a good picture book of trilobites to refer to alongside. Contrary to what some other reviews thought, I believe that to write this book is a very difficult and ambitious proposition. As the author reflects on, the first task of a student is to learn the language; it would be easy to bury me in Latin and technical terms that I could not (and would not want to) remember. The author gives a nice selection of advanced reading so perhaps it is my responsibility to learn the language if I want to learn more.

Brilliant! (from a Trilobite collector).......2005-08-19

I have always loved Trilobites, ever since I found a small fossil on a beach (God knows why it was there, but it felt pretty cool). This book finally helped me understand the animals I had been collecting. Fortey writes with a real passion that any reader can feel. While he doesn't shy away from in-depth science, he invites the reader to join him in understanding geology and paleontology.

I wouldn't necessarily say this book is for a wide audience. However, for those looking for a scientific adventure, this is it!

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Overview of the history of life

Prehistoric Life (Eyewitness Books)
William Lindsay
Manufacturer: Knopf Books for Young Readers
ProductGroup: Book
Binding: Hardcover

Biology | Science, Nature & How It Works | Children's Books | Subjects | Books

General | Ages 9-12 | Children's Books | Subjects | Books

General | Literature | Children's Books | Subjects | Books

General | Evolution | Science | Subjects | Books

Look Inside Children's Books | Trip | Specialty Stores | Books
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ASIN: 0679860010
Release Date: 1994-05-10

Book Description

Full-color photos. Explore the origins of life on earth, from the first algae to the first humans; why life began in the sea, not on land; why dinosaurs ruled the earth for millions of years and then disappeared; and how mammals--and then humans--took over.

Customer Reviews:

Overview of the history of life.......2004-06-12

This book is a good overview of the history of life on earth. There are a lot of great pictures in the book.

Some parents may want to be aware the book presents earth's material from an evolutionary perspective. Although I personally do not think that the scientific case for biological evolution has been definitive proven, I use this book as a supplement to our homeschool curriculum to expose my kids to the basic ideas of evolution. I want them to respect this perspective and not lampoon it. And this book is a great way to introduce kids to the foundational ideas. Parents who do hold an evolutionary perspective will probably appreciate the book for the same reason.

My only slight criticism of this book is that the book gives minimal discussion to the multiple extinction and replacement events that have happened throughout the history of the earth. This is an intriguing issue of earth's history which very few textbooks give any discussion to.

My other criticism is that the book doesn't clearly differentiate between modern humans and hominids, their differing behaviors and culture. But, again, this isn't unusual. Many science textbooks don't seem to make this differentiation either.

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Excellent Reference Work For Children

Historical /Sensitive Coverage of Evolution Teen Appropriate

Eyewitness: Evolution
Linda Gamlin
Manufacturer: DK CHILDREN
ProductGroup: Book
Binding: Hardcover

General | Reference & Nonfiction | Children's Books | Subjects | Books
Biology | Science, Nature & How It Works | Children's Books | Subjects | Books
General | Science, Nature & How It Works | Children's Books | Subjects | Books
General | Ages 9-12 | Children's Books | Subjects | Books
General | Evolution | Science | Subjects | Books
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Eyewitness: Life

Early Humans (DK Eyewitness Books)

Darwin and Evolution for Kids: His Life and Ideas with 21 Activities (For Kids series)

Eyewitness: Prehistoric Life

Life on Earth: The Story of Evolution

ASIN: 078945579X

Book Description

Explore the world of living things, and trace the discoveries that explain the amazing diversity of life on Earth.

The theory of evolution changed our understanding of the natural world -- and Eyewitness Evolution is the perfect way to learn more about it! Discover what life was like millions of years ago; how new species develop; and learn why pandas have false thumbs and penguins stand upright. Superb full-color photographs of animals, plants and fossils make this book a compelling look at evolution.

Customer Reviews:

Excellent Reference Work For Children.......2001-09-02

With a wealth of drawings, pictures, and photographs, this book explains the basics of natural selection and the evolution of life on earth.

The authors also do a good job of confronting issues that have little to do with science but which may nevertheless be raised by some in connection with this branch of human knowledge. References to certain mythological beliefs are done in a professional and non-offensive way, with reasoned explanations of why people may have thought the way they did (or do). This book is highly recommended for children in Middle School who are confronted with class-mates who do not understand evolution or who for some reason have been taught that it is not 'true.'

But the main strength of this book is a strong presentation of the evidence for natural selection that is found in nature. By combining many interesting facts about fascinating animals with a small dose of hard science this book is a perfect introduction to areas of science such as geology and anthropology. As such it also provides much information that will complement Middle School science classes. This book should be in every educated family's library.

Historical /Sensitive Coverage of Evolution Teen Appropriate.......1999-10-04

I was looking for a book on evolution to give to a child who was asking questions about the subject. I found this book in eyewitness fashion to be low on text but told its story through many engaging interesting pictures. The book sensitively dealt with questions of creation and biblic questions relating to evolution, answering them with scientific and historical information. It also provided multicultural references and included creation stories from non-western cultures as well.

Book Description

Full-color photos. "From cover to cover, this openly invites the reader to discover the delights of dinosaurs. The visual appeal is impressive. The text is informative. Fossilization, skeleton reconstruction, and a superb time scale round out a stunning and compelling book. Complete, authoritative, exact, and imaginative, it is sure to survive when other dinosaur books become extinct."--(starred) Science Books & Films.

Customer Reviews:

A little disappointed.......2007-01-13

I have bought several of the DK book for my son (3 1/2 yrs) and have been very happy with all of them, so when he became interested in dinosaurs I thought this would be perfect for him. When I received it though, I was a little disappointed in it. It just didn't seem to have very much variety, as far as the dinosaurs and their names, etc...I ended up getting "Dinosaur Atlas- An amazing journey through a lost world", also by DK, and love it!!! It has exellent and extensive life-like pictures of the dinosaurs, along with the pronunciation and meaning of the names. It also has see-through pages overlaying some of the larger photos, showing the skeletal system of the dinosaur. There is also an interactive cd-rom included, which is kind of limited in what it shows, but a cool little addition. The book also sub-divides the dinosaurs by location, depending on what continent they lived on, and pages showing how and where they lived. There are all sorts of little tid-bits of info interspersed throughout the book (ie: "Did you know?" boxes), making it an even richer book. I love to sit dowon and look at this book with my son, since I learn so much too! I highly recommend this book over the basic Dinosaur book by DK.

Eyewitness books.......2006-11-05

My son loves Eyewitness books and has a modest collection already. Dinosaur is the latest addition. The photos and illustrations are entertaining. The information in the books is well laid out and can hold the interest of kids and adults alike! Everyone can learn something from these books. There are over 100 titles, with new ones coming out all the time. I doubt my son will ever tire of Eyewitness books.

beautifully presented photos and drawings.......2000-07-06

The DK series of eyewitness books are all fabulous, but this has to be my favorite. Dinosaurs are always appealing to children and adults and this book is no disappointment. Superb studio-quality, well lit photographs give you close-up shots of teeth and bones so real, you'll feel like they're right there for you to touch and pick up.

Theories on how dinosaurs really looked on the outside and how they walked are explored. Every caption has a tidbit of information that is interesting to anyone who reads it. A book like this will keep a child of any reading age occupied for no less than an hour on a road trip... and it will constantly be read over and over again... it's just intriguing and beautifully presented.

Great DINOsaur book..........2000-06-17

I appreciate this book because it gives you drawings and paintings of how prehistoric creatures lived millions of years ago. It gives a perfect understanding of the study and also art of Paleontology. This book is, in my opinion, 1 of 2 of my most favorite books ever published for the scientific review of more than just a few species...This concludes my review.

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Dog (DK Eyewitness Guides)
Juliet Clutton-Brock
Manufacturer: Dorling Kindersley Publishers Ltd
ProductGroup: Book
Binding: Hardcover

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Pony Power
Picture Perfect -Horse of course

Horse (DK Eyewitness Guides)
Juliet Clutton-Brock
Manufacturer: Dorling Kindersley Publishers Ltd
ProductGroup: Book
Binding: Hardcover

Zoology | Science, Nature & How It Works | Children's Books | Subjects | Books

General | Evolution | Science | Subjects | Books
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ASIN: 0863187900

Book Description

Discover the world of horses and ponies in close-up -- their behavior and important role in history.

Here is an original and exciting guide to the fascinating world of horses and ponies. Stunning, real-life photographs of horses, ponies, donkeys, mules, wild asses, and zebras offer a unique "eyewitness" view of these remarkable animals, their natural history and role in civilization. See an authentic Wells Fargo stagecoach, a 19th-century woman riding sidesaddle, a performing circus horse, and a real-life jousting tournament. Learn why horses flatten back their ears, how a blacksmith shoes a horse, how horses have been used in wartime, and how a horse's teeth show its age. Discover why a zebra has stripes, which wild asses are now extinct, what a Roman horseshoe looked like, the difference between an English and a Western saddle, what makes horses race, and much, much more.

Customer Reviews:

Pony Power.......2006-07-20

What to learn about the intersting world of horses? If you said yes this is the right book for you! The complete guide of horse colors & breeds. Want to know how the horse looked like over 1,000,000 years ago? Or the bones insde a horse? Well if you want to learn more get this book! After you are done reading this book, play horse triva with a friend... trust me you will win for sure. The photos are amazing, the captions will explain everything you will need to know about the horsey world! So canter to the BUY THIS BOOK button!

Picture Perfect -Horse of course.......2000-05-11

This is a well planned and wonderfully illustrated book on horses, with many great rare photos of exotic members of the horse family. I was truly delighted to find good close up pictures of equines that are on the endangered list and and text written in easy to understand english. For the child or the adult this is a must for the horseman's library.

Eyewitness: Evolution of the Atmospheric Sciences

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Eyewitness: Evolution of the Atmospheric Sciences
Robert G. Fleagle
Manufacturer: Amer Meteorological Society
ProductGroup: Book
Binding: Hardcover

General | Science | Subjects | Books
ASIN: 187822039X

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Natural World (DK Eyewitness Guides)

Manufacturer: Dorling Kindersley Publishers Ltd
ProductGroup: Book
Binding: Hardcover

Biology | Science, Nature & How It Works | Children's Books | Subjects | Books

General | Evolution | Science | Subjects | Books
ASIN: 0751353884

TRILOBITE : EYEWITNESS TO EVOLUTION (VINTAGE)

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TRILOBITE : EYEWITNESS TO EVOLUTION (VINTAGE)
RICHARD FORTEY
Manufacturer: Vintage Books
ProductGroup: Book
Binding: Paperback
ASIN: B000NXI8YO

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