Dynamics of Bone and Cartilage Metabolism, Second Edition: Principles and Clinical Applications

Book Description

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.

*Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components
*Part II covers the organizational structure and cellular metabolism of bone and cartilage
*Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Average customer rating:

First rate ECM reference source
Easy and practical approach to the subject

The Extracellular Matrix Factsbook
Shirley Ayad , Ray Boot-Handford , Martin Humphries , Karl Kadler , and Adrian Shuttleworth
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0120689111

Book Description

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references.

Key Features
* Compiled by members of one of the foremost centers of matrix biochemistry in the world
* Contains over 30 new entries, with all previous entries being revised and updated
* Includes new entries on proteinases involved in the deposition of the extracellular matrix
* Presents 3D ribbon diagrams in cases where the protein structure is now known

Customer Reviews:

First rate ECM reference source.......2004-01-08

I found this to be a very thorough reference across a broad range of extracellular matrix proteins. In particular, identifying which critical ECM proteins to add back to 3D cell culture conditions to re-approximate the in vivo milieu. It was highly touted at http://home.ease.lsoft.com/archives/3d-cell-biology.html and www.puramatrix.com as a key manual for research and bioproduction involving ECM proteins.

Easy and practical approach to the subject.......1999-02-19

Easy to read and most of all usefull in the lab. Worthy to buy

Extracellular Matrix and The Liver: Approach to Gene Therapy

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Extracellular Matrix and The Liver: Approach to Gene Therapy

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 012525251X

Book Description

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses
new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy
approaches.

The chapters are divided into six sections as follows:

* Basic Science of Extracellular Matrix
* Cells Responsible for Extracellular Matrix Production
* Activation Mechanism of Hepatic Cells and Signal Transduction
* Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
* Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
* New Strategies for the treatment of Liver Cirrhosis

Key Features
* Discusses the possibility of gene therapy for liver cirrhosis
* Includes information on new aspects of hepatic stellate cells
* Written by top experts in basic science and clinical hepatology

Fibronectin (Biology of Extracellular Matrix)

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Fibronectin (Biology of Extracellular Matrix)

Manufacturer: Academic Pr
ProductGroup: Book
Binding: Hardcover

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Integrins: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix)

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Integrins: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0121711609

Book Description

Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer.

Key Features
* Describes key aspects of integrin structure, function, and biology
* Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists
* Investigates the expression and role of integrins during development and in the cytoskeleton
* Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis

Cellular Organelles and the Extracellular Matrix (Principles of Medical Biology)

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Cellular Organelles and the Extracellular Matrix (Principles of Medical Biology)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 1559388048

Book Description

This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones.
The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.
Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix: Biological, Chemical, Engineering, and Physiological Aspects

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Mechanosensing and Mechanochemical Transduction in Extracellular Matrix: Biological, Chemical, Engineering, and Physiological Aspects
Frederick H. Silver
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 0387256318

Book Description

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix is the only single authored text on biological polymers available for bioengineering and biomedical engineering students. This book describes the structure of polymers and how these molecules are put together to make the tissues of the body and also their role in surgical implants and in structural diseases.

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix is intended to serve as a textbook at the graduate and advanced undergraduate level in a biomedical engineering curriculum.

Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (The Guidebook Series)

Average customer rating:

A guidebook

Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (The Guidebook Series)

Manufacturer: A Sambrook and Tooze Publication at Oxford University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0198599587

Book Description

This new edition of Guidebook to the Extracellular Matrix and Adhesion Proteins brings up-to-date information on the purification, activities, antibodies and genes for the proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. Since the first edition much has been learned on the structure of these proteins and their diverse roles in cell communication and metabolite exchange. The Sambrook and Tooze guidebooks provide succinct and up-to-date information on particular classes of important biological molecules, accompanied by short bibliographies, which enable both specialists and newcomers to the field to gain access to unfamiliar work. Drawing on a wide range of sources, this volume addresses all aspects of the structure and function of modules in the extracellular matrix, adhesion molecules, cell adhesion and cell-cell contact proteins.

Customer Reviews:

A guidebook.......2000-05-17

Every major adhesion protein is in there. Not for bedtime reading though, as this book is specifically for those who need this sort of detail for their research. (Although it seems there are more than I would have thought as 5 people rated my initial version of this review)

Extracellular Matrix: A Practical Approach (Practical Approach Series)

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Extracellular Matrix: A Practical Approach (Practical Approach Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0199632200

Book Description

The extracellular matrix surrounds cells and tissues. It provides structure to organisms and is important in determining cell growth, state of differentiation, and how the cell responds during injury and development. Changes in the extracellular matrix are also important components in both
inherited and acquired diseases. Thus, studies of the extracellular matrix span much of modern biological research. Because the extracellular matrix resides outside the cell, the properties of the component molecules require special approaches for their study. This volume brings together under a
single cover the majority of the basic techniques employed in extracellular matrix research.

Biological Matrices and Tissue Reconstruction

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Biological Matrices and Tissue Reconstruction

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Book Description

Tissue Engineering, just leaving its egg shells behind may well evolve to a major breakthrough in medicine. Progress in material engineering and biology have made it imaginable in short time to replace lost tissue functions and even lost body parts without the artificial and supply problems of transplantation. In a workshop symposium organized by the European Tissue Repair Society in August 1997 leading scientists from engineering, basic sciences and medicine contributed to this book, which specially stresses the importance of matrix materials for tissue reconstruction and wound healing. Starting with skin, an increasing number of groups is rapidly developing substitutes for most tissues which soon will enter clinical practice.

Book Description

The oceans provide a truly millennial challenge for both the development and management of planet earth by humankind. Awareness of the nature and scale of this challenge, the opportunities and the limitations, has been developing over the past three decades. In particular, new approaches to the development of the law of the sea, the division of the oceans among states, and new thinking on institutions will be needed in the transition to the new millennium. Understanding of the newness of the challenges has to be underpinned by understanding of the uses of the sea in terms of major sectors, and recognition of the importance of the many regional worlds of perception, understanding and action which link the diverse ocean environment to the diversity of human culture.

This book covers all these themes in depth. It is aimed at both academics and students in higher education, and practitioners in the rapidly growing fields of ocean and coastal management in the public, private, and voluntary sectors.

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