DNA and RNA Binders, From Small Molecules to Drugs (2-Volume Set)

Book Description

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Rna Structure and Function (Cold Spring Harbor Monograph Series)

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Rna Structure and Function (Cold Spring Harbor Monograph Series)

Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Paperback

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Book Description

The striking functional versatility of RNA is attributable to its remarkable capacity for conformational change. Current models of RNA synthesis, its maturation, translation, and degradation are all based on specific structures and there is growing appreciation of the functional importance of interactions between RNA and RNA-binding proteins. This book identifies the major intellectual and technical advances in understanding the part played by structure in how RNA works. It encompasses the experimental approaches used to define RNA structure and its influence on RNA functions such as transcription termination, catalysis, recoding, and translational control. Investigators with these interests and students of molecular biology will find this volume a thoroughly up-to-date, provocative survey of a rapidly advancing field and a valuable complement to the recent, highly successful Cold Spring Harbor monograph The RNA World.

Trna: Structure, Biosynthesis, and Function

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Trna: Structure, Biosynthesis, and Function
Dieter Soll
Manufacturer: ASM Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 155581073X

RNA: Protein Interactions: A Practical Approach (Practical Approach Series)

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RNA: Protein Interactions: A Practical Approach (Practical Approach Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0199636508

Book Description

RNA-protein interactions play a vital role in gene transcription and protein expression. Interactions such as the synthesis of mRNA by RNA polymerases, to the essential modification of RNA by the proteins of the spliceosome complex, and the highly catalytic action of the ribosome in protein synthesis, are established as being fundamental to the function of RNA. Recent research into, for example, the role of RNA as a catalyst, has elucidated many more interactions with proteins that are vital to cell function. RNA - Protein Interactions: A Practical Approach provides a clear and comprehensive guide to the experimental procedures used in studying RNA - protein interactions. The approaches covered range from those initially used to detect a novel RNA-protein interaction, various biochemical and genetic approaches to purifying and cloning RNA binding proteins, through to methods for an in depth analysis of the structural basis of the interaction. The volume includes a number of procedures that have not previously been covered in this type of manual. These include the production of site-specifically modified RNAs by enzymatic and chemical methods and in vivo screening for novel RNA - protein interactions in yeast and E. coli . This is the first volume to gather in one place this wide array of approaches for studying RNA - protein interactions. As is customary for the Practical Approach series, the writing is characterized by a clear explanatory style with many detailed protocols. This informative book will be a valuable aid to laboratory workers in biochemistry and molecular biology - graduate students, postdoctoral and senior scientists - whose research encompasses this field.

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Control of Messenger RNA Stability

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0120847825

Book Description

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression.
Key Features
* Provides perspectives from both prokaryotic and eukaryotic systems
* Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression
* Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation
* Evaluates experimental procedures for studying mRNA degradation
Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.

Key Features
* Provides perspectives from both prokaryotic and eukaryotic systems
* Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression
* Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation
* Evaluates experimental procedures for studying mRNA degradation

RNA Interference (RNAi): The Nuts & Bolts of siRNA Technology (Nuts & Bolts Series) (Nuts & Bolts series)

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"Genomics & Proteomics" Book Review 4(4):40, 2004

RNA Interference (RNAi): The Nuts & Bolts of siRNA Technology (Nuts & Bolts Series) (Nuts & Bolts series)
David Engelke
Manufacturer: Dna Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0966402782

Book Description

This work focuses on practical approaches to and uses of a revolutionary technology called RNAi for RNA interference. A recently developed research tool, this process allows scientists to knock out or knock down the levels of a gene product, shut off targeted genes in an organism, and then monitor the results within that organism. Leading academic and biotechnology researchers in various fields that utilize this process introduce and explain a specific model system and use of RNA interference as well as necessary background information. Tools for the Arabidopsis, Caenrhabditis, and Drosophila model organism systems are offered, as is an overview of siRNA design and RNA transfection processes in mammalian cells. A discussion of chemical and enzymatic synthesis and preparation of siRNA in vitro is also included.

Customer Reviews:

"Genomics & Proteomics" Book Review 4(4):40, 2004.......2004-05-09

With the rise and utility of RNA Interference (RNAi) as a useful tool for silencing and manipulating genes, there has been much interest in the specific applications of this technique to various animal models for disease. Because it is a natural phenomenon, RNAi is more robust than other RNA-based methods. However, RNAi pathways do not follow the same rules in different organisms, and therefore, specific information on RNAi methods is essential for each model organism studied.
The aim of "RNA Interference (RNAi): Nuts & Bolts of RNAi Technology" by David Engelke and published by DNA Press (www.dnapress.net) is to serve as a guide for practical RNAi use in the laboratory. The book is short on general theory behind RNAi, except to furnish the bare minimum of background information for each chapter. However, the book is rich in specific protocols for the various methods that are described, including suppliers of reagents and advice on modifications and customizations of protocols.
Chapters include protocols for RNAi in plants, Drosophila, C. elegans, mammalian systems, mice, and discussions of high-throughput RNAi as well as design, synthesis and preparation of synthetic RNAi. An added bonus each chapter contains an ample list of relevant literature references.

Book Description

RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA". It alerts the reader to the importance of regulatory RNA elements for the many different areas of cellular life.
The computational and experimental methods and tools to search for new interesting regulatory RNA structures are explained and compared. The knowledge on regulatory RNA structures and elements already available is concisely summarized as well as catalogued. In addition, interesting RNA elements are analyzed in detail regarding their dynamics, regulation, and as a dominant topic of current resarch in molecular biology, including areas such as RNA mediated regulation of gene-expression, DNA/RNA chip data, and ribozymes, splicing, or telomerases in aging. Medical implications are also covered. Future progress and research are finally outlined.

RNA Binding Proteins: New Concepts in Gene Regulation (Endocrine Updates)

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RNA Binding Proteins: New Concepts in Gene Regulation (Endocrine Updates)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 0792376129

Book Description

RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.
Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.

Rna-Protein Interaction Protocols (Methods in Molecular Biology)

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First step

Rna-Protein Interaction Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0896035689

Book Description

Highly skilled experimentalists provide a comprehensive series of commonly used, as well as specialized, techniques for analyzing how proteins and RNA interact. Richly detailed and readily reproducible, these methods enable researchers to analyze the structural details of an RNA-protein interaction, to determine in detail what parts of the protein and RNA are in close contact, and to isolate RNP complexes from cells. There are also in vitro and in vivo methods and protocols for assaying the effects of proteins and RNP complexes on mRNA metabolism. The methods assume only a knowledge of basic molecular biology, biochemistry, and cell culture, and can be readily adapted to other systems. RNA-Protein Interaction Protocols offers a wide-ranging collection of up-to-date experimental methods that will assure productive and reproducible results for all investigators in the field.

Customer Reviews:

First step.......2000-10-23

This book is really good for beginner. RNA-Protein interaction in transcription, post-transcription and translation is really interest and important. So this book will be a guide for research which intrested in this mechanism.

Rna Methodologies: A Laboratory Guide for Isolation and Characterization

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Not advanced and back-dated
great methods book

Rna Methodologies: A Laboratory Guide for Isolation and Characterization
Robert E., Jr. Farrell
Manufacturer: Academic Pr
ProductGroup: Book
Binding: Paperback

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Book Description

This laboratory guide is a collection of tested and optimized laboratory protocols for the isolation and characterization of eukaryotic RNA. This edition includes a variety of RNA-based PCR techniques, such as differential display PCR, and transcript quantification by competitive (mimic) PCR. The book focuses on how these methodologies can be used in the study of transcriptional and posttranscriptional regulation of eukaryotic genes. The liberal incorporation of flow charts, tables, and graphs facilitate learning and assist in the planning phases of projects. It is a valuable resource for investigators who wish to characterize cellular biochemistry.

Key Features
* Studies cellular biochemistry using RNA as a parameter of gene expression
* Unifies many facets of working with RNA
* Offers multiple isolation strategies directed to the same experimental end
* Explains proper handling, storage, and manipulation of RNA
* Includes classic and contemporary techniques
* Contains fully annotated protocols, as well as rationale for each protocol
* Incorporates flow charts, tables, and graphs to facilitate learning and assist in the planning phases of projects

Customer Reviews:

Not advanced and back-dated.......2004-12-02

I am a RNA-chemist and I bought this book from amazon.com to get help for my day-to-day research. The moment I had my first glance at this book I was frustrated. This book has described fairly old methods but no contemporary techniques. This book is not even descrided the techniques in an advanced manner which is expected for a book based on so specific field. I would not recommend this book to anyone who has atleast the basic working knowledge of molecular biology.

great methods book.......2000-05-16

This book is exactly what it claims to be--a laboratory guide. It provides methods that are clear, but also explains the reasons for the methods. For example: when is an RNA probe better than a DNA probe and why; when nonisotopic labels can be used effectively. Although there is not a chapter on in situ hybridization, I found the section on probes very helpful. There is also a handy glossary at the end and a primer on RNA at the beginning of the book. Dr Farrell realizes the reader maybe new to the field and so doesn't leave out the basics. However, I believe this book will be helpful to all but the most knowledgable molecular biolgists.

Book Description

This book-and-CD-software package supplies users with an interactive experience for nuclear visualization via a computer-graphical interface, similar in principle to the molecular visualizations already available in chemistry. Models of the Atomic Nucleus, a largely non-technical introduction to nuclear theory, explains the nucleus in a way that makes nuclear physics as comprehensible as chemistry or cell biology. The book/software supplements virtually any of the current textbooks in nuclear physics by providing a means for 3D visual display of the diverse models of nuclear structure. For the first time, an easy-to-master software for scientific visualization of the nucleus makes this notoriously "non-visual" field become immediately ‘visible.’ After a review of the basics, the book explores and compares the competing models, and addresses how the lattice model best resolves remaining controversies. The appendix explains how to obtain the most from the software provided on the accompanying CD.

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