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Functional Protein Microarrays in Drug Discovery (Drug Discovery Series)
Manufacturer: CRC
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Binding: Hardcover
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ASIN: 0849398096 |
Book Description
An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications. The book discusses the generation of functional protein content and describes both standard and state-of-the-art fabrication methods. It reviews current and next generation approaches to assay detection and presents a wide range of applications, from biomolecular interaction discovery and characterization to immune response profiling. The book also addresses several fundamental computational issues, bioinformatics anddata analysis.
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Mathematical Methods for Protein Structure Analysis and Design: Advanced Lectures (Lecture Notes in Computer Science)
Manufacturer: Springer
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Binding: Paperback
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ASIN: 3540401040 |
Book Description
The revised lectures presented in this volume are based on a course given by leading scholars at the C.I.M.E. Summer School held in Martina Franca, Italy, in July 2000.
The 11 revised chapters presented were carefully revised and cross-reviewed in order to provide competent coverage of mathematical methods for protein structure analysis and design. The topics addressed pinpoint major issues arising in the development and analysis of models, algorithms, and software tools devoted to the structure of proteins, all of which play crucial roles in structural genomics and proteomics.
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Peptide and Protein Drug Analysis (Drugs and the Pharmaceutical Sciences)
Manufacturer: CRC
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Binding: Hardcover
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ASIN: 0824778596 |
Book Description
Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis · discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability · analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology · examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods · highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry · demonstrates uses of unnatural mutagenesis and combinatorial chemistry · explores mass spectrometry, protein sequence, and carbohydrate analysis · illustrates bioassays and other new functional analysis methods · surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) · addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells · reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering · and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
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Protein Structural Analysis, Folding and Design
Manufacturer: Elsevier Science Ltd
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Binding: Hardcover
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ASIN: 0444813233 |
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Proteins: Analysis and Design
Manufacturer: Academic Press
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ASIN: 0120587858 |
Book Description
Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function.
Key Features:
* Provides problems and technical solutions
* Includes posttranslational modifications
* Uses synthetic peptides as biological models
* Details mutagenesis and protein engineering
* Covers design of protein structure and function
Book Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
The creation of synthetic tailor-made receptors capable of recognizing desired molecular targets with high affinity and selectivity is a persistent long-term goal for researchers in the fields of chemical, biological, and pharmaceutical research. Compared to biomacromolecular receptors, these synthetic receptors promise simplified production and processing, less costs, and more robust receptor architectures. During recent decades, molecularly imprinted polymers (MIPs) are widely considered mimics of natural molecular receptors suitable for a diversity of applications ranging from biomimetic sensors, to separations and biocatalysis. A remaining challenge for the next generation of MIPs is the synthesis of deliberately designed and highly efficient receptor architectures suitable for recognizing biologically relevant molecules, for which natural receptors are either not prevalent, or difficult to isolate and utilize. Hence, this review discusses recent advances in synthetic receptor technology for biomolecules (e.g. drugs, amino acids, steroids, proteins, entire cells, etc.) via molecular imprinting techniques. Surface imprinting methods and epitope imprinting approaches have been introduced for protein recognition at imprinted surfaces. Imprinting techniques in aqueous solution or organic-water co-solvents have been introduced avoiding denaturation of biomolecules during MIP synthesis. In addition, improved bioreactivity of entire enzyme or active site mimics generated by molecular imprinting will be highlighted. Finally, the emerging importance of molecular modeling and molecular dynamics studies detailing the intermolecular interactions between the template species, the porogenic solvent molecules, and the involved monomer and cross-linker in the pre-polymerization solution will be addressed yielding a rational approach toward next-generation MIP technology.
Book Description
Though we heavily rely on historical performance, the figures reported in this report are not historical but are forecasts and projections for the coming fiscal year. The forecasts are updated quarterly. This particular report was updated in the last quarter. In order to maintain comparability over time and across companies and countries, we use an index system. In the case of a firm's assets, we treat the total assets as equaling 100, irrespective of the value of the local currency. All other assets are then calculated as a percent from total assets. In this way, the structure of the firm's assets can be easily interpreted and compared with international benchmarks. For liabilities, total liabilities and equity are indexed to equal to 100. For the income statement, total revenue is indexed to equal 100, and all other figures are calculated as a percent of these figures. Ratios are projected using raw financial statistics and, as ratios, are therefore comparable. The source(s) for the various raw statistics include public filings, corporate releases, and various other data sources.
Given a company's financial structure, the resulting figures are benchmarked across "leading competitors". In choosing the leading competitors, Icon Group chooses only those firms with sound financial situations or those not undergoing radical restructuring, or where random volatility, mergers, or bankruptcy affects financial performance.
Since the calculation of competitors' benchmarks proceeds in a similar fashion, but are aggregated across all competitors, one can directly conduct a financial gap analysis. Here, Icon Group graphically reports, for each part of the financial statement, the larger gaps that the firm has vis-a-vis the leading competitors. A gap need not be a bad sign. Rather, it is simply a substantial difference that might merit further attention or signal a firm's relative strength or weakness for t
Download Description
Though we heavily rely on historical performance, the figures reported in this report are not historical but are forecasts and projections for the coming fiscal year. The forecasts are updated quarterly. This particular report was updated in the last quarter. In order to maintain comparability over time and across companies and countries, we use an index system. In the case of a firm's assets, we treat the total assets as equaling 100, irrespective of the value of the local currency. All other assets are then calculated as a percent from total assets. In this way, the structure of the firm's assets can be easily interpreted and compared with international benchmarks. For liabilities, total liabilities and equity are indexed to equal to 100. For the income statement, total revenue is indexed to equal 100, and all other figures are calculated as a percent of these figures. Ratios are projected using raw financial statistics and, as ratios, are therefore comparable. The source(s) for the various raw statistics include public filings, corporate releases, and various other data sources.
Given a company's financial structure, the resulting figures are benchmarked across "leading competitors". In choosing the leading competitors, Icon Group chooses only those firms with sound financial situations or those not undergoing radical restructuring, or where random volatility, mergers, or bankruptcy affects financial performance.
Since the calculation of competitors' benchmarks proceeds in a similar fashion, but are aggregated across all competitors, one can directly conduct a financial gap analysis. Here, Icon Group graphically reports, for each part of the financial statement, the larger gaps that the firm has vis-a-vis the leading competitors. A gap need not be a bad sign. Rather, it is simply a substantial difference that might merit further attention or signal a firm's relative strength or weakness for t
Book Description
The goal of this report is to assist managers in gauging a company's financial performance vis-a-vis firms competing in the same sector, at the global level. In particular, this report covers PROTEIN DESIGN LABS, INC., MOUNTAIN VIEW, USA. With the globalization of markets, greater foreign competition, and the reduction of entry barriers, it becomes all the more important to benchmark a company's performance against other firms on a worldwide basis. Doing so, however, is not an obvious task. First, one needs to find firms competing in the same sector. Second, one needs to control for exchange rate volatility. Finally, one needs to use comparable financial standards. This report overcomes these issues and gives full financial benchmarks vis-a-vis worldwide competitors who are present in the same narrow industrial classification. Benchmarks cover assets, liabilities, income and ratios. Since our reports are printed on demand, the statistics reported are for the latest quarter and are the most up to date available (4 reports are produced each year). Each report provides over 100 statistics and 40 graphs to the reader.
Book Description
Though we heavily rely on historical performance, the figures reported in this report are not historical but are forecasts and projections for the coming fiscal year. The forecasts are updated quarterly. The source(s) for the various raw statistics include public filings, corporate releases, and various other data sources.
Given a company's financial structure, the resulting figures are benchmarked across "leading competitors". In choosing the leading competitors, Icon Group chooses only those firms with sound financial situations or those not undergoing radical restructuring, or where random volatility, mergers, or bankruptcy affects financial performance.
Since the calculation of competitors' labor ratios proceeds in a similar fashion, but are aggregated across all competitors, one can directly conduct a gap analysis. Here, Icon Group graphically reports, for each labor productivity area the larger gaps that the firm has vis-a-vis the leading competitors. A gap need not be a bad sign. Rather, it is simply a substantial difference that might merit further attention or signal a firm's relative strength or weakness for the coming fiscal year...
Download Description
Though we heavily rely on historical performance, the figures reported in this report are not historical but are forecasts and projections for the coming fiscal year. The forecasts are updated quarterly. The source(s) for the various raw statistics include public filings, corporate releases, and various other data sources.
Given a company's financial structure, the resulting figures are benchmarked across "leading competitors". In choosing the leading competitors, Icon Group chooses only those firms with sound financial situations or those not undergoing radical restructuring, or where random volatility, mergers, or bankruptcy affects financial performance.
Since the calculation of competitors' labor ratios proceeds in a similar fashion, but are aggregated across all competitors, one can directly conduct a gap analysis. Here, Icon Group graphically reports, for each labor productivity area the larger gaps that the firm has vis-a-vis the leading competitors. A gap need not be a bad sign. Rather, it is simply a substantial difference that might merit further attention or signal a firm's relative strength or weakness for the coming fiscal year...
Book Description
This book is designed for human resources managers and directors of personnel who are concerned with labor productivity. It gives benchmarks and gap analyses used to gauge a company's performance vis-a-vis firms competing firms in the same sector, at the global level. In particular, this report covers PROTEIN DESIGN LABS, INC., MOUNTAIN VIEW, USA. With the globalization of markets, greater foreign competition, and the reduction of entry barriers, it becomes all the more important to benchmark a company's performance against other firms on a worldwide basis. Doing so, however, is not an obvious task. First, one needs to find firms competing in the same sector. Second, one needs to control for exchange rate volatility. Finally, one needs to use comparable financial standards. This report overcomes these issues and gives full human resources benchmarks vis-a-vis worldwide competitors who are present in the same narrow industrial classification. Benchmarks cover labor-asset ratios, labor-liability ratios, and labor-income ratios. Since our reports are printed on demand, the statistics reported are for the latest quarter and are the most up to date available (4 updates are produced each year). Each report provides over 100 statistics and 40 graphs to the reader.
Book Description
Aimed at graduate physics and chemistry students, this is the first comprehensive monograph covering the concept of the geometric phase in quantum physics from its mathematical foundations to its physical applications and experimental manifestations. It contains all the premises of the adiabatic Berry phase as well as the exact Anandan-Aharonov phase. It discusses quantum systems in a classical time-independent environment (time dependent Hamiltonians) and quantum systems in a changing environment (gauge theory of molecular physics). The mathematical methods used are a combination of differential geometry and the theory of linear operators in Hilbert Space. As a result, the monograph demonstrates how non-trivial gauge theories naturally arise and how the consequences can be experimentally observed. Readers benefit by gaining a deep understanding of the long-ignored gauge theoretic effects of quantum mechanics and how to measure them.
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In Vivo EPR (ESR): Theory & Applications (Biological Magnetic Resonance)
Manufacturer: Springer
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ASIN: 0306477904 |
Book Description
In Vivo EPR (ESR) is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging.
Key Features:
-History of In Vivo EPR,
-Principles of Imaging-Theory and Instrumentation,
-Time-domain Radio Frequency EPR Imaging,
-The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques,
-Potential Medical (Clinical) Applications of EPR,
-Combining NMR and EPR/ESR for In Vivo Experiments.
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NMR in Microbiology : Theory and Applications
ProductGroup: Book
Binding: Hardcover
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ASIN: 1898486212 |
Book Description
Nuclear Magnetic Resonance is one of the most powerful tools available to scientists for the elucidation of the structures of macromolecules, and for the non-invasive analysis of metabolism. NMR is a vital resource required to complement the vast amount of data generated by the genome projects. A fundamental knowledge of the theory and applications of NMR is now vital to all researchers in microbiology, molecular biology and biotechnology. In this comprehensive volume leading international researchers review in depth virtually every aspect of this important topic. In addition, the basic principles of NMR are explained for scientists who have no prior knowledge of the subject. This volume will serve as a valuable reference work for all scientists.
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High Resolution NMR: Theory and Chemical Applications, 3rd Edition
Edwin D. Becker
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover
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ASIN: 0120846624 |
Book Description
High Resolution NMR provides a broad treatment of the principles and theory of nuclear magnetic resonance (NMR) as it is used in the chemical sciences. It is written at an "intermediate" level, with mathematics used to augment, rather than replace, clear verbal descriptions of the phenomena. The book is intended to allow a graduate student, advanced undergraduate, or researcher to understand NMR at a fundamental level, and to see illustrations of the applications of NMR to the determination of the structure of small organic molecules and macromolecules, including proteins. Emphasis is on the study of NMR in liquids, but the treatment also includes high resolution NMR in the solid state and the principles of NMR imaging and localized spectroscopy.
Careful attention is given to developing and interrelating four approaches - steady state energy levels, the rotating vector picture, the density matrix, and the product operator formalism. The presentation is based on the assumption that the reader has an acquaintance with the general principles of quantum mechanics, but no extensive background in quantum theory or proficiency in mathematics is required. Likewise, no previous background in NMR is assumed, since the book begins with a description of the basic physics, together with a brief account of the historical development of the field.
This third edition of High Resolution NMR preserves the "conversational" approach of the previous editions that has been well accepted as a teaching tool. However, more than half the material is new, and the remainder has been revised extensively. Problems are included to reinforce concepts in the book.
Key Features
* Uses mathematics to augment, not replace, verbal explanations
* Written in a clear and conversational style
* Follows the successful format and approach of two previous editions
* Revised and updated extensively--about 70 percent of the text is new
* Includes problems and references to additional reading at the end of each chapter
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Calculation of NMR and EPR Parameters: Theory and Applications
Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover
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ASIN: 3527307796 |
Book Description
This is the first book to present the necessary quantum chemical methods for both resonance types in one handy volume, emphasizing the crucial interrelation between NMR and EPR parameters from a computational and theoretical point of view.
Here, readers are given a broad overview of all the pertinent topics, such as basic theory, methodic considerations, benchmark results and applications for both spectroscopy methods in such fields as biochemistry, bioinorganic chemistry as well as with different substance classes, including fullerenes, zeolites and transition metal compounds. The chapters have been written by leading experts in a given area, but with a wider audience in mind.
The result is the standard reference on the topic, serving as a guide to the best computational methods for any given problem, and is thus an indispensable tool for scientists using quantum chemical calculations of NMR and EPR parameters.
A must-have for all chemists, physicists, biologists and materials scientists who wish to augment their research by quantum chemical calculations of magnetic resonance data, but who are not necessarily specialists in these methods or their applications. Furthermore, specialists in one of the subdomains of this wide field will be grateful to find here an overview of what lies beyond their own area of focus.
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Density Functional Theory and its Application to Materials: Antwerp, Belgium, 8-10 June 2000 (AIP Conference Proceedings)
Manufacturer: American Institute of Physics
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ASIN: 0735400164 |
Book Description
An overview of the state of the art in density functional theory is presented. Not only the recent theoretical developments but also the achievements in calculating mechanical and electronic properties of molecules, polymers, and solids are described. Recent developments related to the construction of exchange-correlation functionals used in density functional theory for ground and excited states are presented. Applications to materials modeling in general as well as to nanotubes, quantum dots, and artificial molecules are incorporated. Topics such as optical excitations, critical temperatures of superconductors, and state-of-the-art Monte Carlo calculations are also discussed.
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Dissociative Recombination: Theory, Experiments and Applications : Proceedings of the 1999 Conference, Stockholm, Sweded, 16-20 June 1999
Manufacturer: World Scientific Publishing Company
ProductGroup: Book
Binding: Hardcover
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ASIN: 9810240775 |
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Introduction to Multinuclear Nmr: Theory and Application
Claude H. Yoder , and
Charles D., Jr. Schaeffer
Manufacturer: Benjamin-Cummings Publishing Company
ProductGroup: Book
Binding: Paperback
Analytic
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ASIN: 0805397507 |
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Multiparticle Quantum Scattering with Applications to Nuclear, Atomic and Molecular Physics (The IMA Volumes in Mathematics and its Applications)
Manufacturer: Springer
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Binding: Hardcover
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ASIN: 0387949992 |
Book Description
The topics in this volume include the ideas of mathematicians, physicists and chemists in the area of multiparticle scattering theory. Scattering theory (or collision theory as it is often called) is a fundamental area of theory and computation in both physics and chemistry. The correct formulation of scattering theory for two-body collisions is now well worked out, but systems with three or more particles still present fundamental unmet challenges, both in the formulations of the problem and in the interpretation of computational results. A key issue in the mathematical foundations is asymptotic completeness, which says that any state of a quantum system is a superposition of bound and scattering states. Key issues on the physical side are concerned with boundary conditions, electromagnetic fields, effective potentials and resonances.
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NMR Spectroscopy Explained: Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology
Neil E. Jacobsen
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover
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ASIN: 0471730963 |
Book Description
NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments.
- Introduces students to modern NMR as applied to analysis of organic compounds.
- Presents material in a clear, conversational style that is appealing to students.
- Contains comprehensive coverage of how NMR experiments actually work.
- Combines basic ideas with practical implementation of the spectrometer.
- Provides an intermediate level theoretical basis for understanding laboratory experiments.
- Develops concepts gradually within the context of examples and useful experiments.
- Introduces the product operator formalism after introducing the simpler (but limited) vector model.
Books:
- Fungal Disease Resistance in Plants: Biochemistry, Molecular Biology, and Genetic Engineering (Crop Science) (Crop Science)
- Fungal Morphogenesis (Developmental and Cell Biology Series)
- General Zoology Laboratory Guide
- Genomes and Genomics of Nitrogen-fixing Organisms (Nitrogen Fixation: Origins, Applications, and Research Progress)
- Gold and Silver Staining: Techniques in Molecular Morphology (Advances in Pathology, Microscopy, & Molecular Morphology)
- Goldfish Varieties and Genetics: A Handbook for Breeders
- Green Plants: Their Origin and Diversity
- Handbook of Behavioral Neurobiology, Volume 12: Circadian Clocks (Handbooks of Behavioral Neurobiology)
- Health Measurement Scales: A Practical Guide to Their Development and Use (Oxford Medical Publications)
- Heterotrimeric G Proteins (Methods in Enzymology)
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