Enzyme Kinetics and Mechanism

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A lot of information, but not-so-well explained..........2005-04-13

With an undergrad degree in chemistry and a year of graduate school (granted, without a focus solely in biochemistry), this text was often difficult for me to follow and gain much from. Though the text contained an impressive breadth of topics, this breadth came at the cost of depth. In my opinion, a textbook should more-or-less stand on its own in providing a clear understanding of a topic. All too often I didn't find this to be the case with the Fersht book. Instead, I often had to consult many of the references listed in the text to obtain sufficient understanding of topics. (Fortunately, the book includes extensive reference lists.) If looking up endless references (many old and sometimes difficult to obtain) is something you enjoy, this book is for you.--If not, forget it!

Highly recommend it.......2003-08-31

Hands down the bible of enzyme kinetics!

Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.

essential.......2002-05-01

If you are studying protein structure, you probably should read this book for reference.

This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.

Some texts are difficult to understand, or dry, or facile. This is not one of those texts.

Biochemists Can't Miss.......2001-08-23

The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.

Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.

Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

The Mother of All Enzyme Books.......2001-01-10

Man, this book rocked! I took one look at the ribbon structure of ATPase on the cover and said to myself, "Whoa dude! This is, like, phat!" Then I turned the pages and BAM! I was knee deep in protein structure! Like, any first-year biochemist knows its all about the acids, as in amino, and Fersht, he knows his peptides! Oh man, I was on cloud nine! And I've been off my meds for two months now! But you wanna know the real dope? You can't say diddly about function unless you know structure, and that Alan, as in Fersht, dude! Like, he starts you off simple, like, you know, with the "building blocks," like we're a bunch of two-year-olds, and you string 'em together and get all that higher-order structure and stuff, and slowly, ever so slowly, like a mental itch that invades your consciousness and becomes screaming voices telling you to AHHHHHHHHH! So many domains! Too many functional units! No, no, nooooooo! Schiff base? Shift Bass! Ah HA HA HA HA! What do all those K's mean!?! Take me home! Please...

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Enzymatic Reaction Mechanisms
Perry A. Frey , and Adrian D. Hegeman
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195122585

Book Description

Books Dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

The Enzymes, Volume 1: Kinetics, Mechanism, Thermodynamics, Basic Properties

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The Enzymes, Volume 1: Kinetics, Mechanism, Thermodynamics, Basic Properties
Paul D.; Lardy, Henry & Myrback, Karl Boyer
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000K3G87Q

Contemporary Enzyme Kinetics and Mechanism (Selected Methods in Enzymology)

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Contemporary Enzyme Kinetics and Mechanism (Selected Methods in Enzymology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback

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ASIN: 012568052X

Book Description

Kinetic studies of enzyme action provide powerful insights into the underlying mechanisms of catalysis and regulation. These approaches are equally useful in examining the action of newly discovered enzymes and therapeutic agents.
Contemporary Enzyme Kinetics and Mechanism, Second Edition presents key articles from Volumes 63, 64, 87, and 249 of Methods in Enzymology. The chapters describe the most essential and widely applied strategies. A set of exercises and problems is included to facilitate mastery of these topics.
The book will aid the reader to design, execute, and analyze kinetic experiments on enzymes. Its emphasis on enzyme inhibition will also make it attractive to pharmacologists and pharmaceutical chemists interested in rational drug design.
Of the seventeen chapters presented in this new edition, ten did not previously appear in the first edition.

Key Features
* Transient kinetic approaches to enzyme mechanisms
* Designing initial rate enzyme assay
* Deriving initial velocity and isotope exchange rate equations
* Plotting and statistical methods for analyzing rate data
* Cooperativity in enzyme function
* Reversible enzyme inhibitors as mechanistic probes
* Transition-state and multisubstrate inhibitors
* Affinity labeling to probe enzyme structure and function
* Mechanism-based enzyme inactivators
* Isotope exchange methods for elucidating enzymatic catalysis
* Kinetic isotope effects in enzyme catalysis
* Site-directed mutagenesis in studies of enzyme catalysis

Behavior of enzyme systems;: An analysis of kinetics and mechanism

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Behavior of enzyme systems;: An analysis of kinetics and mechanism
John M Reiner
Manufacturer: Burgess Pub. Co
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Binding: Unknown Binding

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ASIN: B0006AVYZO

Enzymatic Mechanisms (Biomedical and Health Research, 27)

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Enzymatic Mechanisms (Biomedical and Health Research, 27)

Manufacturer: Ios Pr Inc
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Binding: Hardcover

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Book Description

Nineteen ninety-eight marks the thirty-fifth anniversary of the publication of Professor W. Wallace Cleland's landmark papers on the steady-state kinetics of multisubstrate enzymes in Biochim. Biophys. Acta 67, 104, 173, & 188 (1963). Since then, methods such as spectroscopy, x-ray crystallography, chemical synthesis and analysis, and site directed mutagenesis have been introduced, and all play essential roles in enhancing and refining modern pictures of how enzymes work in structural terms. However, the inspiration for all mechanistic studies of enzymes is their kinetic behavior, and the relevance and significance of structural information is determined by its compatibility with underlying kinetic facts. In recognition of Professor Cleland's important papers, Enzymatic Mechanisms was chosen as the topic for the 1998 Steenbock Symposium. The papers presented at this symposium are published in this volume. The global approach to mechanistic analysis is emphasized, while highlighting the kinetic basis for enzymatic research. Internationally known figures in the field of enzyme mechanisms have contributed papers.

The Enzyme Catalysis Process:Energetics, Mechanism and Dynamics (Nato a S I Series Series a, Life Sciences)

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The Enzyme Catalysis Process:Energetics, Mechanism and Dynamics (Nato a S I Series Series a, Life Sciences)

Manufacturer: Springer
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Enzyme Kinetics and Mechanism (Methods in Enzymology, Vol. 63)

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A Classic

Enzyme Kinetics and Mechanism (Methods in Enzymology, Vol. 63)

Manufacturer: Academic Press
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Book Description

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

Customer Reviews:

A Classic.......2007-03-02

The Methods in Enzymolgy series is probably the most useful and respectable series of books for those of use who actually work in this field. This volume is a classic, even at almost 30 years old it is still excellent.

Enzyme Kinetics and Mechanism, Part B: Isotopic Probes and Complex Enzyme Systems, Volume 64: Volume 64: Enzyme Kinetics and Mechanism Part B (Methods in Enzymology)

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Enzyme Kinetics and Mechanism, Part B: Isotopic Probes and Complex Enzyme Systems, Volume 64: Volume 64: Enzyme Kinetics and Mechanism Part B (Methods in Enzymology)

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Methods in Enzymology, Volume 311: Sphingolipid Metabolism and Cell Signaling, Part A (Methods in Enzymology)

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Chemistry co-op at the University of Victoria: full spectrum education. (Focus on Education) (Cover Story): An article from: Canadian Chemical News

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Chemistry co-op at the University of Victoria: full spectrum education. (Focus on Education) (Cover Story): An article from: Canadian Chemical News
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This digital document is an article from Canadian Chemical News, published by Chemical Institute of Canada on March 1, 1995. The length of the article is 1524 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Chemistry co-op at the University of Victoria: full spectrum education. (Focus on Education) (Cover Story)
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A master of science teaching degree program for high school teachers. (South Dakota State University) (Focus on Education) (Cover Story): An article from: Canadian Chemical News

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A master of science teaching degree program for high school teachers. (South Dakota State University) (Focus on Education) (Cover Story): An article from: Canadian Chemical News
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This digital document is an article from Canadian Chemical News, published by Chemical Institute of Canada on March 1, 1995. The length of the article is 988 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: A master of science teaching degree program for high school teachers. (South Dakota State University) (Focus on Education) (Cover Story)
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Planning for understanding: a project-based mentorship model for the high school curriculum. (Chemical Institute of Canada) (Focus on Education) (Cover Story): An article from: Canadian Chemical News

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Planning for understanding: a project-based mentorship model for the high school curriculum. (Chemical Institute of Canada) (Focus on Education) (Cover Story): An article from: Canadian Chemical News
Jo Young
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This digital document is an article from Canadian Chemical News, published by Chemical Institute of Canada on March 1, 1995. The length of the article is 1996 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Planning for understanding: a project-based mentorship model for the high school curriculum. (Chemical Institute of Canada) (Focus on Education) (Cover Story)
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Solid color deck stains: trends, substrates, and formulation study.(Technology Today)(Cover story): An article from: JCT CoatingsTech

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Solid color deck stains: trends, substrates, and formulation study.(Technology Today)(Cover story): An article from: JCT CoatingsTech
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Title: Solid color deck stains: trends, substrates, and formulation study.(Technology Today)(Cover story)
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University perspective on high school enrichment programs. (chemistry programs) (Focus on Education) (Cover Story): An article from: Canadian Chemical News

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University perspective on high school enrichment programs. (chemistry programs) (Focus on Education) (Cover Story): An article from: Canadian Chemical News
George C. Hickling
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Release Date: 2005-07-28

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This digital document is an article from Canadian Chemical News, published by Chemical Institute of Canada on March 1, 1995. The length of the article is 2222 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: University perspective on high school enrichment programs. (chemistry programs) (Focus on Education) (Cover Story)
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