Video Microscopy, Volume 56 (Methods in Cell Biology (Paper), 56)

Book Description

Video microscopy is used extensively in many life and biomedical science disciplines today, and is a useful tool for both cell biologists and students. This book presents how to track the dynamic changes that take place in the structure of living cells and in reconstituted preparations using video and digital imaging microscopy. Basic information, principles, and applications are also covered, as well as more specialized video microscopy techniques.

Key Features
* Chapters cover the commonly used video technologies in biological research
* Nontechnical presentation of principles
* Emphasis on the practical aspects of instrument use
* Covers pitfalls in instrument uses that can lead to artifacts
* Authors are leaders in the design and application of video methods to biological microscopy
* Presentation of material tailored for the established researcher that has little experience with video methods
* Examples are extensively illustrated with photographs

Video Microscopy, Volume 56 (Methods in Cell Biology (Paper), 56)

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Video Microscopy, Volume 56 (Methods in Cell Biology (Paper), 56)
Greenfield Sluder
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OHTBPO

Book Description

This book is a comprehensive manual to allow both the novice researcher and the expert to set up and carry out quantitative PCR assays from scratch. However, this book also sets out to explain as many features of qPCR as possible, provide alternative viewpoints, methods, and aims to simulate the researchers into generating, interpreting, and publishing data that are reproducible, reliable, and biologically meaningful

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My favorite book...

Dynamics of Proteins and Nucleic Acids
J Andrew McCammon , and Stephen C. Harvey
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0521356520

Book Description

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

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My favorite book..........2005-09-07

This is my favorite book on molecular simulations. I was amazed to find that it's still in print. (Just to avoid conflicts of interest, I should mention that I'm one of the authors.) - Steve Harvey

Principles of Nucleic Acid Structure (Springer Advanced Texts in Chemistry)

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Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure (Springer Advanced Texts in Chemistry)
Wolfram Saenger
Manufacturer: Springer
ProductGroup: Book
Binding: Paperback

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Nucleic Acids: Structures, Properties, and Functions

ASIN: 0387907610

Book Description

During the last decade the advances in molecular biology have increasingly emphasized the importance of the hydrogen bond in biological interactions. Hydrogen-bonding in assemblages of biological molecules examined from the structural point of view is a main focus of the present book. Hydrogen-bonding is thereby defined in its broadest sense, as many attractive interactions involving a covalently bonded hydrogen atom. The concept of the hydrogen bond structure is developed, as is the role of cooperativity, in stabilizing particular structures and hydrogen-bonding dynamics. The information presented is based on the extraordinary increase in quantitative structural data that has become available from X-ray and neutron diffraction studies of crystal structures involving small and large biological molecules. Included are structural data of particular types of hydrogen bonds as well as data for different types of molecules, such as carbohydrates, purines and pyrimidines, nucleosides and nucleotides, ices and hydrates, cyclodextrins, nucleic acids and proteins.

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Principles of Nucleic Acid Structure.......2000-05-02

Fantastic book, the best review of structural information onnucleic acids in print. A must for any laboratory that works withnucleic acids. END

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Nucleic Acid Testing for Human Disease

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 157444543X

Book Description

Nucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended for routine use. It focuses on specific applications of NATs to human disease diagnosis and treatment, from viral, bacterial, fungal, and protozoan detection to genetic exploration by SNP determinations, patterns of RNA expression, and the growing relevance of epigenetic changes. It also offers different perspectives on future directions in the field.

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Nucleic Acids in Chemistry and Biology

Manufacturer: Royal Society of Chemistry
ProductGroup: Book
Binding: Hardcover

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ASIN: 0854046542

Book Description

Nucleic Acid in Chemistry and Biology 3rd edition, has been extensively updated from previous editions. Featuring an expanded group of editors and contributors this leading textbook offers a thorough background in all modern aspects of Nucleic Acid Chemistry and Biology. Coverage includes:

- both the chemistry and biology of nucleic acids

- the chemical synthesis of nucleosides and nucleotides

- the chemistry for the synthesis of oligonucleotides and analogues

This book provides an excellent overview of the chemistry and biology of nucleic acids, at a level that is suitable for use in university teaching, but with enough detail to be useful as a reference source for chemists, biochemists and biologists involved in current research of nucleic acids.

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Triple Helical Nucleic Acids
Valery N. Soyfer , and Vladimir N. Potaman
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Book Description

The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Perspectives in Nucleoside and Nucleic Acid Chemistry

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Perspectives in Nucleoside and Nucleic Acid Chemistry

Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover

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ASIN: 3906390217

Book Description

The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside- and nucleotide-based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug-development and genome-sequencing research.
This volume, comprised of contributions written by internationally recognized experts, covers cutting-edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state-of-the-art overview.

Quadruplex Nucleic Acids (Biomolecular Sciences Series)

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Quadruplex Nucleic Acids (Biomolecular Sciences Series)

Manufacturer: Royal Society of Chemistry
ProductGroup: Book
Binding: Hardcover

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Sequence-specific DNA Binding Agents (Biomolecular Sciences Series)

ASIN: 0854043748

Book Description

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered.

Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered.

Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Nucleoside Mimetics: Their Chemistry and Biological Properties (Advanced Chemistry Texts)

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Nucleoside Mimetics: Their Chemistry and Biological Properties (Advanced Chemistry Texts)
Claire Simons
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 9056993240

Book Description

Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites. Nucleoside Mimetics provides an introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic and asymmetric synthesis. The book gives a comprehensive introduction to nucleosides and coverage of the various classes. The aim of Nucleoside Mimetics is to provide the reader with a useful insight into the diversity of nucleosides, the range of elegant chemistry involved and the continuing importance of nucleosides as both therapeutic agents and as probes for studying biochemical processes.

Molecular Diagnostics: Fundamentals, Methods, & Clinical Applications

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Molecular Diagnostics: Fundamentals, Methods, & Clinical Applications
Lela, Ph.D. Buckingham , and Maribeth L., Ph.D. Flaws
Manufacturer: F. A. Davis Company
ProductGroup: Book
Binding: Paperback

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ASIN: 0803616597

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